… In this review, we ask questions about the role of senescent brain cells in brain plasticity
and cognitive functions impairments and how senolytics can improve them. We will discuss …

… In the following sections, we review studies reporting senescence in post-mitotic brain cells.
We evaluate the methods used by key studies and compare them to our pre-defined criteria …

… Emerging evidence shows that various types of brain cells, including oligodendrocyte
precursor cells (OPCs), astrocytes, microglia, and neurons, express higher levels of …

… This review summarizes the main findings on the role of cellular senescence in the … cell
cycle arrest associated with cellular senescence, the reduced regenerative capacities of the brain …

… senescent cells in neurodegenerative diseases. In the final section, we review how cell
senescence … Cell senescence on these types of brain cells may lead to impaired myelination and …

… The question arises whether senescence-induced inflammation … of cellular senescence
as a driver of the aging phenotype, and discuss the current evidence that connects senescence …

… to DNA damage or other cellular stresses. We discuss evidence for endothelial cell senescence
in ageing and cardiovascular disease, and how CEC senescence may contribute to age-…

… are not cleared then the accumulation of senescent cells becomes greater with time, … as a
pro-senescence stimulus and induces cellular senescence in different brain cell types, leading …

… In MS, accelerated cellular senescence may drive disease … blood-brain barrier integrity
and ultimately neurodegeneration. Here we discuss the evidence linking cellular senescence to …

… Cellular senescence as a central aging mechanism is potentially involved in the
progression of brain aging to MCI and AD. Although the preclinical animal models to study the …