… therapeutic alternatives to treat Chagas disease, though … to treat Chagas disease and
benefit the populations it affects. … have been made to improve the Chagas disease treatment. …

… for combinatorial therapy for the treatment of Chagas disease. … the treatment of Chagas
disease. We believe that drug discovery in Chagas disease in the near future should advance by …

… aged between 2 and 12 years old with Chagas disease and was the first drug to be approved
in the US for the treatment of Chagas disease. Since the introduction of BZN and NFX, only …

… Other repositioning drugs potentially useful in the ancillary treatment of Chagas disease
were clomipramine, sertraline and fexinidazole. Clomipramine, a tricyclic antidepressant, was …

… Chagas disease is a neglected tropical disease caused by … available for the treatment of
Chagas disease and both have … preclude the development of new treatments, some of them …

… Afterward, different clinical and experimental studies were published using benznidazole
as a treatment for acute and chronic Chagas disease; it became the first-line treatment in both …

… strategies on the treatment of Chagas disease, as well as a general overview of nanovaccines
and nanodiagnostics. Figure 1 Nanomaterials used against Chagas disease. Strategies …

… Tropical Diseases 20 announced plans for the elimination or control of Chagas disease
by 2020, current estimates indicate that less than 1% of CD-infected patients are treated and …

… We explore recent developments in Chagas disease diagnosis, reviewing historical context
and advancements. Despite progress, challenges persist. This article contributes to the …

… Here, we will provide an overview of the current status of Chagas disease drug development,
highlight those areas where progress can be expected, and describe how fundamental …