Aneuploidy and DNA methylation as mirrored features of early human embryo development
EN Tolmacheva, SA Vasilyev, IN Lebedev - Genes, 2020 - mdpi.com
… these stages is such that we can only guess what an imbalance of DNA methylation may
contribute to incorrect chromosome segregation at this stage—the hypomethylation of repetitive …
contribute to incorrect chromosome segregation at this stage—the hypomethylation of repetitive …
DNA methylation-based sex classifier to predict sex and identify sex chromosome aneuploidy
… chromosomes, thousands of CpG sites on autosomes also show very different DNA methylation
patterns … co-variate, when undertaking methylation and phenotype association studies. …
patterns … co-variate, when undertaking methylation and phenotype association studies. …
Evaluation of genome-wide DNA methylation profile of human embryos with different developmental competences
M Yang, X Tao, K Scott, Y Zhan, RT Scott Jr… - Human …, 2021 - academic.oup.com
… between DNA methylation level and ploidy status (aneuploidy [n … the DNA methylation level
on the chromosome scale. … have lower methylation level on the involved chromosome while …
on the chromosome scale. … have lower methylation level on the involved chromosome while …
Losing DNA methylation at repetitive elements and breaking bad
XG Pappalardo, V Barra - Epigenetics & chromatin, 2021 - Springer
… DNA methylation is an epigenetic … chromosome stability) by controlling both gene expression
and chromatin structure. Therefore, the onset of an incorrect pattern of DNA methylation is …
and chromatin structure. Therefore, the onset of an incorrect pattern of DNA methylation is …
Keeping the centromere under control: a promising role for DNA methylation
A Scelfo, D Fachinetti - Cells, 2019 - mdpi.com
… , observed in certain tumors, has been correlated to aneuploidy … the DNA methylation pattern
of its underlying sequences. … DNA methylation may also have an impact on chromosome …
of its underlying sequences. … DNA methylation may also have an impact on chromosome …
DNA methylation episignatures: insight into copy number variation
L der Laan, K Rooney, TMA Trooster… - …, 2022 - Taylor & Francis
… are limited in detection of smaller aberrations (<3 Mb) [Citation35] and are currently
primarily used for detection of whole chromosome aneuploidies or balanced rearrangements. …
primarily used for detection of whole chromosome aneuploidies or balanced rearrangements. …
Aneuploidy and gene expression: is there dosage compensation?
… 8, but no changes in DNA methylation of gene promoter regions on chromosome 8 [… of DNA
methylation on other chromosomes [Citation77]. An older study examined DNA methylation …
methylation on other chromosomes [Citation77]. An older study examined DNA methylation …
DNA methylation loss promotes immune evasion of tumours with high mutation and copy number load
… , we investigated the relationships between methylation changes and aneuploidy. …
chromosomal copy number changes. Our data show that the particular association of chromosomal …
chromosomal copy number changes. Our data show that the particular association of chromosomal …
Detection of aberrant DNA methylation patterns in sperm of male recurrent spontaneous abortion patients
RH Ma, ZG Zhang, YT Zhang, SY Jian, BY Li - Zygote, 2023 - cambridge.org
… Some evidence has suggested that the risk of aneuploidy embryos in the high DFI group
was 55% … Plus, DNA methylation can impact the stability of chromosomes, and chromosomal …
was 55% … Plus, DNA methylation can impact the stability of chromosomes, and chromosomal …
Effects of aneuploidy on cell behaviour and function
… 21, which stimulates de novo DNA methylation 95 . Altered DNA methylation patterns were
… with various numbers of group 1 homologous chromosomes 96 . Remarkably, the altered …
… with various numbers of group 1 homologous chromosomes 96 . Remarkably, the altered …