Aneuploidy and DNA methylation as mirrored features of early human embryo development

EN Tolmacheva, SA Vasilyev, IN Lebedev - Genes, 2020 - mdpi.com
… these stages is such that we can only guess what an imbalance of DNA methylation may
contribute to incorrect chromosome segregation at this stage—the hypomethylation of repetitive …

DNA methylation-based sex classifier to predict sex and identify sex chromosome aneuploidy

Y Wang, E Hannon, OA Grant, TJ Gorrie-Stone… - BMC genomics, 2021 - Springer
chromosomes, thousands of CpG sites on autosomes also show very different DNA methylation
patterns … co-variate, when undertaking methylation and phenotype association studies. …

Evaluation of genome-wide DNA methylation profile of human embryos with different developmental competences

M Yang, X Tao, K Scott, Y Zhan, RT Scott Jr… - Human …, 2021 - academic.oup.com
… between DNA methylation level and ploidy status (aneuploidy [n … the DNA methylation level
on the chromosome scale. … have lower methylation level on the involved chromosome while …

Losing DNA methylation at repetitive elements and breaking bad

XG Pappalardo, V Barra - Epigenetics & chromatin, 2021 - Springer
DNA methylation is an epigenetic … chromosome stability) by controlling both gene expression
and chromatin structure. Therefore, the onset of an incorrect pattern of DNA methylation is …

Keeping the centromere under control: a promising role for DNA methylation

A Scelfo, D Fachinetti - Cells, 2019 - mdpi.com
… , observed in certain tumors, has been correlated to aneuploidy … the DNA methylation pattern
of its underlying sequences. … DNA methylation may also have an impact on chromosome

DNA methylation episignatures: insight into copy number variation

L der Laan, K Rooney, TMA Trooster… - …, 2022 - Taylor & Francis
… are limited in detection of smaller aberrations (<3 Mb) [Citation35] and are currently
primarily used for detection of whole chromosome aneuploidies or balanced rearrangements. …

Aneuploidy and gene expression: is there dosage compensation?

S Kojima, D Cimini - Epigenomics, 2019 - Taylor & Francis
… 8, but no changes in DNA methylation of gene promoter regions on chromosome 8 [… of DNA
methylation on other chromosomes [Citation77]. An older study examined DNA methylation

DNA methylation loss promotes immune evasion of tumours with high mutation and copy number load

H Jung, HS Kim, JY Kim, JM Sun, JS Ahn… - Nature …, 2019 - nature.com
… , we investigated the relationships between methylation changes and aneuploidy. …
chromosomal copy number changes. Our data show that the particular association of chromosomal

Detection of aberrant DNA methylation patterns in sperm of male recurrent spontaneous abortion patients

RH Ma, ZG Zhang, YT Zhang, SY Jian, BY Li - Zygote, 2023 - cambridge.org
… Some evidence has suggested that the risk of aneuploidy embryos in the high DFI group
was 55% … Plus, DNA methylation can impact the stability of chromosomes, and chromosomal

Effects of aneuploidy on cell behaviour and function

R Li, J Zhu - Nature Reviews Molecular Cell Biology, 2022 - nature.com
… 21, which stimulates de novo DNA methylation 95 . Altered DNA methylation patterns were
… with various numbers of group 1 homologous chromosomes 96 . Remarkably, the altered …