Glycosylation of biosimilars: Recent advances in analytical characterization and clinical implications

BL Duivelshof, W Jiskoot, A Beck, JL Veuthey… - Analytica chimica …, 2019 - Elsevier
… in immunogenicity and clinical efficacy of therapeutic proteins. … of glycan characterization
on therapeutic proteins, with a … to illustrate the potential clinical implications of differences in …

Pathological implication of protein post-translational modifications in cancer

S Pan, R Chen - Molecular aspects of medicine, 2022 - Elsevier
… Given the pivotal role of protein glycosylation in many biological processes and the
tendency of glycoprotein entering circulation, malignancy associated glycoproteins represent …

Glycosylation and Its Role in Immune Checkpoint Proteins: From Molecular Mechanisms to Clinical Implications

J Liu, X Xu, H Zhong, M Yu, N Abuduaini, S Zhang… - Biomedicines, 2024 - mdpi.com
… Many immune checkpoints are known to be heavily glycosylated. Since glycosylation helps
maintain protein stability and mediate proteinprotein interactions, the study of glycosylation

Glycosylation and its implications in breast cancer

DA Scott, RR Drake - Expert review of proteomics, 2019 - Taylor & Francis
… the potential clinical implications and utility of analyzing changes in serum glycosylation
, we predict that the roles of glycosylation in clinical breast cancer research will center around …

The impact of PD-L1 N-linked glycosylation on cancer therapy and clinical diagnosis

YN Wang, HH Lee, JL Hsu, D Yu, MC Hung - Journal of biomedical …, 2020 - Springer
… Notably, the removal of N-linked glycosylation enhances PD-… important clinical implication
of PD-L1 N-linked glycosylation. … L1 N-linked glycosylation could shed new light on the clinical

Glycosylation of cancer extracellular vesicles: capture strategies, functional roles and potential clinical applications

ÁM Martins, CC Ramos, D Freitas, CA Reis - Cells, 2021 - mdpi.com
… In this review, the application of EV glycosylation in the … the potential of EV glycosylation
in the clinical setting for both … the potential clinical application of the EV glycosylation in anti-…

Global view of human protein glycosylation pathways and functions

KT Schjoldager, Y Narimatsu, HJ Joshi… - … reviews Molecular cell …, 2020 - nature.com
… explore protein glycosylation through analysing and targeting enzymes involved … glycosylation
processes. In silico models predicting cellular glycosylation capacities and glycosylation

Implications of glycosylation in Alzheimer's disease

H Haukedal, KK Freude - Frontiers in Neuroscience, 2021 - frontiersin.org
… of glycans to both proteins and lipids. There are two major types of protein glycosylation; the
addition of N-linked glycans and O-linked glycans (Figure 3). N-glycosylation takes place in …

Glycosylation in health and disease

C Reily, TJ Stewart, MB Renfrow, J Novak - Nature Reviews Nephrology, 2019 - nature.com
… Perhaps the most diverse form of protein glycosylation is O-glycosylation, … protein and
the additional sugar structures added to the initial glycan. For example, mucin-type O-glycosylation

The role of O-glycosylation in human disease

A Magalhães, HO Duarte, CA Reis - Molecular Aspects of Medicine, 2021 - Elsevier
… (GalNAc) O-glycosylation occurs in the Golgi apparatus. Some other forms of protein
glycosylation are initiated in the ER, such as protein N-glycosylation, being further processed and …