Glycosylation of biosimilars: Recent advances in analytical characterization and clinical implications
… in immunogenicity and clinical efficacy of therapeutic proteins. … of glycan characterization
on therapeutic proteins, with a … to illustrate the potential clinical implications of differences in …
on therapeutic proteins, with a … to illustrate the potential clinical implications of differences in …
Pathological implication of protein post-translational modifications in cancer
S Pan, R Chen - Molecular aspects of medicine, 2022 - Elsevier
… Given the pivotal role of protein glycosylation in many biological processes and the
tendency of glycoprotein entering circulation, malignancy associated glycoproteins represent …
tendency of glycoprotein entering circulation, malignancy associated glycoproteins represent …
Glycosylation and Its Role in Immune Checkpoint Proteins: From Molecular Mechanisms to Clinical Implications
J Liu, X Xu, H Zhong, M Yu, N Abuduaini, S Zhang… - Biomedicines, 2024 - mdpi.com
… Many immune checkpoints are known to be heavily glycosylated. Since glycosylation helps
maintain protein stability and mediate protein–protein interactions, the study of glycosylation …
maintain protein stability and mediate protein–protein interactions, the study of glycosylation …
Glycosylation and its implications in breast cancer
DA Scott, RR Drake - Expert review of proteomics, 2019 - Taylor & Francis
… the potential clinical implications and utility of analyzing changes in serum glycosylation …
, we predict that the roles of glycosylation in clinical breast cancer research will center around …
, we predict that the roles of glycosylation in clinical breast cancer research will center around …
The impact of PD-L1 N-linked glycosylation on cancer therapy and clinical diagnosis
… Notably, the removal of N-linked glycosylation enhances PD-… important clinical implication
of PD-L1 N-linked glycosylation. … L1 N-linked glycosylation could shed new light on the clinical …
of PD-L1 N-linked glycosylation. … L1 N-linked glycosylation could shed new light on the clinical …
Glycosylation of cancer extracellular vesicles: capture strategies, functional roles and potential clinical applications
ÁM Martins, CC Ramos, D Freitas, CA Reis - Cells, 2021 - mdpi.com
… In this review, the application of EV glycosylation in the … the potential of EV glycosylation
in the clinical setting for both … the potential clinical application of the EV glycosylation in anti-…
in the clinical setting for both … the potential clinical application of the EV glycosylation in anti-…
Global view of human protein glycosylation pathways and functions
… explore protein glycosylation through analysing and targeting enzymes involved … glycosylation
processes. In silico models predicting cellular glycosylation capacities and glycosylation …
processes. In silico models predicting cellular glycosylation capacities and glycosylation …
Implications of glycosylation in Alzheimer's disease
H Haukedal, KK Freude - Frontiers in Neuroscience, 2021 - frontiersin.org
… of glycans to both proteins and lipids. There are two major types of protein glycosylation; the
addition of N-linked glycans and O-linked glycans (Figure 3). N-glycosylation takes place in …
addition of N-linked glycans and O-linked glycans (Figure 3). N-glycosylation takes place in …
Glycosylation in health and disease
C Reily, TJ Stewart, MB Renfrow, J Novak - Nature Reviews Nephrology, 2019 - nature.com
… Perhaps the most diverse form of protein glycosylation is O-glycosylation, … protein and
the additional sugar structures added to the initial glycan. For example, mucin-type O-glycosylation …
the additional sugar structures added to the initial glycan. For example, mucin-type O-glycosylation …
The role of O-glycosylation in human disease
… (GalNAc) O-glycosylation occurs in the Golgi apparatus. Some other forms of protein
glycosylation are initiated in the ER, such as protein N-glycosylation, being further processed and …
glycosylation are initiated in the ER, such as protein N-glycosylation, being further processed and …
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