… evade MEK inhibition, and this often involves a re-wiring of the MAPK pathway to reactivate
… by which they can promote cell signaling, and reactivation of RTKs following MEK inhibition …

… pathway reactivation in a large panel (n = 34) of KRAS-mutant cell lines, by measuring the
reduction of phospho-MEK … We also found that combining SHP2 and MEK inhibitors led to …

… However, incomplete pathway suppression or pathway reactivation is a major issue …
combined RAF and MEK inhibitors, as MEK inhibition can suppress the resultant ERK reactivation. …

… We show that no combination of feedbacks coming from the pathway … Combining two RAF
inhibitors blocks ERK pathway reactivation more effectively than combining RAF and MEK …

… Second, the cotargeting of MEK and resistance pathways by combining MEKi with partner
… In summary, the reactivation of the PI3K-AKT-mTOR pathway and its complex crosstalk with …

… on the BRAF/MEK/ERK pathway.Combined BRAF inhibitor (BRAFi) and MEK inhibitor (MEKi) …
ERK pathway reactivation has also been observed in melanoma mouse models12 and …

… BRAF-independent activation of MEK, combining BRAF and MEK inhibitors (MEKi; eg … of
ERK-dependent signaling pathways since ERK reactivation is a common resistance mechanism…

… We conclude that CRAF reactivation limits the activity of single-agent MEK/ERK inhibitors in
… how combining trametinib with SHP2, FGFR or ERK1/2 inhibitors affected MAPK pathway …

… However, we reported that radiation combined with MEK/ERK inhibitor treatment in in vivo
… durable targets in MEK inhibition therapy, in which MAPK pathway reactivation occurs early, …

… effects of trametinib, a MEK inhibitor, on neuroblastoma with MAPK pathway mutations. As
we … combination group, the tumors gradually grew after seven weeks with MAPK reactivation. …