… a combination therapy targeting feedback reactivation would … that feedback reactivation of
the MAPK pathway and EGFR … in CRC, and that the combination of MEK inhibitors and anti-…

… the MAPK pathway on the level of RAF, 19 potentially enabling MAPK pathway reactivation
after … We investigated potential antitumoral effects of ulixertinib in combination with MEK …

… Combined treatment of metastatic melanoma with BRAF and MEK inhibitors has improved
… converge in the reactivation of the BRAF–MEK–ERK pathway usually following NRAS …

… reactivation of MAPK pathway, via NRAS mutations, and activation of the cell cycle pathway,
… be sensitive to the combination of inhibiting the MAPK and cell cycle pathway. Both BRAFi/…

… patients after about year due to reactivation of the MAPK pathway. [8] One way, the MAPK …
(2) feedback reactivation of the MAPK pathway. [5,11] The ERK/MEK inhibitor combination has …

… pathway is frequently associated with the reactivation of this … to BRAF inhibition or combined
BRAF/MEK inhibition [59,60], … preceding development of resistance to MEK inhibition [61]. …

… that combining MEK inhibition … pathways that alone or in combination cause or regulate
intrinsic and adaptive resistance. This includes, for example, reactivation of the MAPK pathway …

… inhibitor (PD98059) and PI3K inhibitor (PI-103) blocked Akt reactivation, impaired double-…
and MEK/ERK pathways. If both pathways are not blocked, the inhibition of one pathway can …

… It was previously shown that the combination of MEK and … previously reported that combining
a MEK inhibitor (trametinib) … signaling networks leading to reactivation of the pathway, with …

… Here we show that ripretinib treatment in combination with MEK … Our results show that
the combination of KIT and MEK … pathway mutations that result in reactivation of the MAPK …