… minocycline prophylactic treatment was evaluated and compared to its post-injury treatment
in a rat model of spinal cord … Interestingly, our results showed that minocycline pretreatment …

… for treatment of spinal cord injured rats [20]. This drug incites the axonal growth at the site of
injury … We hypothesized that a combination of MH and PTX could be a promising treatment …

… to promote locomotor function after spinal cord injury. In this study, we have tested the
efficacy of combined treatment with minocycline and OECs after contusive spinal cord injury. …

… cord injury (TSCI) induces a powerful inflammatory response that can significantly exacerbate
the extent and severity of neural damage (termed as “secondary injury”). … at the injury site. …

… morphine treatment with minocycline. We found that pre-treatment with minocycline reduced
… More importantly, minocycline also blocked the adverse effects of morphine on recovery of …

… In agreement, we found minocycline treatment could activate autophagy and suppress
PI3K/Akt/mTOR signalling pathway. Furthermore, we used the PI3K/Akt inhibitor LY294002 and …

… apoptosis can be of great help during spinal cord injury (SCI) recovery. In this study, …
minocycline hydrochloride (MH) and dextran sulfate (DS) to target their delivery to the site of injury to …

… Additionally, according to prior studies, minocycline treatment after SCI increases activity of
superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) [108, 204]. Furthermore, …

… MINO also prevents lipid peroxidation in models of TBI and spinal cord injury suggesting that
… in models of spinal cord injury [38]. Preclinical Testing of Minocycline in TBI Animal Models …

… In the present study, the rats were administered with minocycline following spinal cord injury
… spinal cord injury was evaluated through TUNEL assay and demonstrated that minocycline …