Genome-wide CpG density and DNA methylation analysis method (MeDIP, RRBS, and WGBS) comparisons

D Beck, M Ben Maamar, MK Skinner - Epigenetics, 2022 - Taylor & Francis
… in DNA methylation methods involves CpG density. The current study was designed to
investigate the CpG density … and correlate this to various DNA methylation analysis data sets. The …

[HTML][HTML] Local CpG density affects the trajectory and variance of age-associated DNA methylation changes

J Higham, L Kerr, Q Zhang, RM Walker, SE Harris… - Genome Biology, 2022 - Springer
… We analyze longitudinal human DNA methylation trajectories at 345,895 CpGs from 600 …
epigenetic changes at individual CpGs. We show that changes in methylation with age occur at …

CG dinucleotides enhance promoter activity independent of DNA methylation

D Hartl, AR Krebs, RS Grand, T Baubec, L Isbel… - Genome …, 2019 - genome.cshlp.org
… with our previous findings that CpGs indeed protect against DNA methylation. These CpG-poor …
We previously argued that DNA methylation is generally repressive at high CpG density (…

A practical guide to the measurement and analysis of DNA methylation

BD Singer - American journal of respiratory cell and molecular …, 2019 - atsjournals.org
… Integration with ChIP-seq can be performed by examining DNA methylation at well-observed
CpGs across putative enhancers identified by occupancy of histone 3 lysine 4 …

DNA methylation methods: Global DNA methylation and methylomic analyses

S Li, TO Tollefsbol - Methods, 2021 - Elsevier
DNA methylation analysis technologies primarily based on the initial treatments of DNA
For example, heavily methylated CpG sites were found in the gene bodies of transcriptional …

Validation of a DNA methylation microarray for 285,000 CpG sites in the mouse genome

CA Garcia-Prieto, D Álvarez-Errico, E Musulen… - Epigenetics, 2022 - Taylor & Francis
… Following the great acceptance of the human DNA methylation microarrays, … DNA methylation
microarray (Infinium Mouse Methylation BeadChip) that interrogates 280,754 unique CpG

Quantitative comparison of within-sample heterogeneity scores for DNA methylation data

M Scherer, A Nebel, A Franke, J Walter… - Nucleic acids …, 2020 - academic.oup.com
… Most studies are limited to the average DNA methylation levels of individual CpGs and
thus neglect heterogeneity within the profiled cell populations. To assess this within-sample …

[HTML][HTML] DNA methylation: Precise modulation of chromatin structure and dynamics

S Li, Y Peng, AR Panchenko - Current opinion in structural biology, 2022 - Elsevier
… Subsequent studies combing MNase-seq and NOMe-seq data demonstrated that increasing
methylated CpG density was correlated with nucleosome occupancy in the human genome […

CoMeBack: DNA methylation array data analysis for co-methylated regions

E Gatev, N Gladish, S Mostafavi, MS Kobor - Bioinformatics, 2020 - academic.oup.com
… Then, since array-probe coverage of genomic CpGs is sparse, our algorithm would evaluate
… genomic CpGs of a specified density between them. We set the density of genomic CpGs

Expression regulation of genes is linked to their CpG density distributions around transcription start sites

H Tian, Y He, Y Xue, YQ Gao - Life Science Alliance, 2022 - life-science-alliance.org
… We analyzed the RNA-seq, histone modification, and DNA methylation data of the liver,
lung… , and H3K36me3) and possess low DNA methylation levels around TSS, consistent with …