Detrimental impact of the IL-33/ST2 axis in an animal infection model with Cryptococcus neoformans

K Ueno, Y Miyazaki - Allergology International, 2023 - jstage.jst.go.jp
… In bronchial pathology, IL-33M increased the level of mucus secreted by mucus producing
goblet cells, as visualized by periodic acid-Schiff (PAS) staining, whereas IL-33FL did not …

Adaptive immunology of Cryptococcus neoformans infections—an update

J Chen, J Shao, M Dai, W Fang, Y Yang - Frontiers in immunology, 2023 - frontiersin.org
… Furthermore, the fungal load and mucus production in mice increases significantly with
increased pulmonary allergic inflammation. Although Th1 cells play a protective role, Th2 cells …

Dectin‐2‐mediated signaling triggered by the cell wall polysaccharides of Cryptococcus neoformans

D Tanno, R Yokoyama, K Kawamura… - Microbiology and …, 2019 - Wiley Online Library
… cells upon in vitro stimulation with C. neoformans. Furthermore, in in vivo experiments,
accelerated Th2 response and IL-4-dependent mucin production was observed in lungs infected …

Functional Characterization of the GlcNAc Catabolic Pathway in Cryptococcus deneoformans

…, L Shen, Y Kuang, Y Wang, Y Peng, C Hu… - Applied and …, 2022 - Am Soc Microbiol
… size, melanin production, and antifungal drug resistance in Cryptococcus neoformans (9). …
GlcNAc in host lung mucins, the function of GlcNAc on host colonization of C. deneoformans …

Extension of O-Linked Mannosylation in the Golgi Apparatus Is Critical for Cell Wall Integrity Signaling and Interaction with Host Cells in Cryptococcus neoformans …

EJ Thak, YJ Son, DJ Lee, H Kim, JH Kim, SB Lee… - MBio, 2022 - Am Soc Microbiol
… has a null mutation of MSB2 encoding a mucin-like transmembrane protein involved in …
immune cells, we quantified the production of the proinflammatory cytokines tumor necrosis …

Intranasal inoculation of Cryptococcus neoformans in mice produces nasal infection with rapid brain dissemination

C Coelho, E Camacho, A Salas, A Alanio… - MSphere, 2019 - Am Soc Microbiol
… intranasal infections and observed that all produce rapid brain dissemination. Additionally, …
Yeasts were abundant in airways, surrounded with a material that likely represented mucus

Investigation of Antifungal Mechanisms of Thymol in the Human Fungal Pathogen, Cryptococcus neoformans

KW Jung, MS Chung, HW Bai, BY Chung, S Lee - Molecules, 2021 - mdpi.com
neoformans is distinct from the conserved antifungal effect caused by ROS production in
other fungi. Our results show that thymol did not induce intracellular ROS production. In …

A comparative study of IL-33 and its receptor ST2 in a C57BL/6 J mouse model of pulmonary Cryptococcus neoformans infection

Z Wang, Q Ma, J Jiang, X Yang, E Zhang, Y Tao… - Medical Microbiology …, 2023 - Springer
… In the present study, the reduced mucus production in the IL-33 −/− infected … mucus production
and survival extension. Of note, goblet cell hyperplasia and increased mucus production

Glucuronoxylomannan intranasal challenge prior to Cryptococcus neoformans pulmonary infection enhances cerebral cryptococcosis in rodents

HH Lee, DJ Carmichael, V Ríbeiro, DN Parisi… - PLoS …, 2023 - journals.plos.org
… the cryptococcal cells stained with mucin carmine (indicated with arrows; Scale bar: 20 μm).
… [34,50], the ELISA and IF data produced in this investigation demonstrated that in delivery of …

PAMPs and host immune response in cryptococcal infection

K Sato, K Kawakami - Medical Mycology Journal, 2022 - jstage.jst.go.jp
… anticryptococcal activity through production of nitric oxide. Clin … gamma-producing
Cryptococcus neoformans strain results in … mucin production in the lungs after pulmonary infection …