Current gaps in sepsis immunology: new opportunities for translational research

I Rubio, MF Osuchowski, M Shankar-Hari… - The Lancet infectious …, 2019 - thelancet.com
… in sepsis, but the current view of how sepsis affects immunity, and vice versa, is still rudimentary.
The European Group on Immunology of Sepsis … alterations predispose to sepsis, key …

[HTML][HTML] Circulating histones in sepsis: potential outcome predictors and therapeutic targets

Y Li, D Wan, X Luo, T Song, Y Wang, Q Yu… - Frontiers in …, 2021 - frontiersin.org
… of pro-inflammatory cytokines and vascular endothelial injury in sepsis which unfortunately
… cells and macrophages, pro-inflammatory cytokine release and cellular activation and injury (…

[HTML][HTML] Sepsis-induced cardiac dysfunction: a review of pathophysiology

R Habimana, I Choi, HJ Cho, D Kim, K Lee… - Acute and Critical …, 2020 - ncbi.nlm.nih.gov
… The release of chemical mediators such as cytokines during sepsis raises the mitochondrial
Ca 2+ content by increasing Ca 2+ leakage from the sarcoplasmic reticulum and decreasing …

[HTML][HTML] Long-term cognitive outcomes after sepsis: a translational systematic review

T Barichello, P Sayana, VV Giridharan… - Molecular …, 2019 - Springer
… NLRP-1 expression in septic patients compared to healthy controls; the expression levels
of the pro-inflammatory cytokines IL-1β and IL-18 were higher in septic patients with a greater …

[HTML][HTML] DAMPs and NETs in sepsis

NL Denning, M Aziz, SD Gurien, P Wang - Frontiers in immunology, 2019 - frontiersin.org
… They found that when given early after induction of sepsis by CLP, DNase increased pro-inflammatory
cytokines and worsened renal and pulmonary damage. However, when given at a …

From traditional biochemical signals to molecular markers for detection of sepsis after burn injuries

B Muñoz, R Suárez-Sánchez… - Burns, 2019 - Elsevier
… by the production and release of cytokines and monocyte/macrophage dysfunction, which
also can result in many complications, such as septic shock, massive organ dysfunction, and …

[HTML][HTML] Metabolic alterations in sepsis

W Wasyluk, A Zwolak - Journal of clinical medicine, 2021 - mdpi.com
… At this point, we would only like to emphasize the role of the cytokine storm in the pathogenesis
of sepsis. The most important pro-inflammatory cytokines are interleukin 1 (IL-1), IL-6 and …

Nanotools for sepsis diagnosis and treatment

L Papafilippou, A Claxton, P Dark… - Advanced …, 2021 - Wiley Online Library
… Continuous exposure to LPS induces a deregulation of inflammatory cytokines in the
bloodstream, known to trigger sepsis. [ 116 ] Inhibition of LPS is a promising strategy for sepsis

T-cell activation profiles distinguish hemophagocytic lymphohistiocytosis and early sepsis

V Chaturvedi, RA Marsh, A Zoref-Lorenz… - Blood, The Journal …, 2021 - ashpublications.org
… for distinguishing HLH from early sepsis or healthy controls. We conclude that the cytokine
storm of HLH is marked by distinctive T-cell activation whereas early sepsis is not, and that …

[PDF][PDF] Role of Interleukin-6 and Interleukin-8 Cytokines as early diagnostic markers of sepsis

M Moniruzzaman, AK Chowdhury… - Bangladesh Journal of …, 2019 - academia.edu
… made to correlate cytokine levels with sepsis and patient prognosis. Among the cytokines,
IL-6 … These cytokines also stimulate release of acutephase reactants such as CRP and PCT. …