Nanonization techniques to overcome poor water-solubility with drugs
FLO Da Silva, MBDF Marques, KC Kato… - Expert opinion on drug …, 2020 - Taylor & Francis
… The poor water solubility can drastically affect the dissolution rate and, together with
presystemic metabolism events, the drug levels absorbed into the systemic circulation could be …
presystemic metabolism events, the drug levels absorbed into the systemic circulation could be …
The role of functional excipients in solid oral dosage forms to overcome poor drug dissolution and bioavailability
… ) exhibit poor solubility and low dissolution rates in aqueous … low as a result of their poor
solubility properties. In order to … to improve their aqueous solubility and dissolution rates. With …
solubility properties. In order to … to improve their aqueous solubility and dissolution rates. With …
Eutectic mixtures as an approach to enhance solubility, dissolution rate and oral bioavailability of poorly water-soluble drugs
… However, many drugs currently used and in development have poor water solubility and
belong to Classes II and IV of the Biopharmaceutical Classification System (BSC), ie, have low …
belong to Classes II and IV of the Biopharmaceutical Classification System (BSC), ie, have low …
Overview of nanoparticulate strategies for solubility enhancement of poorly soluble drugs
KU Khan, MU Minhas, SF Badshah, M Suhail, A Ahmad… - Life Sciences, 2022 - Elsevier
… route is poor bioavailability which is due to poor solubility and permeability. Poor soluble …
Enhancement and improvement in solubility and dissolution rate respectively is required for …
Enhancement and improvement in solubility and dissolution rate respectively is required for …
[HTML][HTML] A nano-cocrystal strategy to improve the dissolution rate and oral bioavailability of baicalein
J Pi, S Wang, W Li, D Kebebe, Y Zhang, B Zhang… - Asian journal of …, 2019 - Elsevier
… low solubility, dissolution rate and poor oral absorption limit the therapeutic applications. In
this work, a nano-cocrystal strategy was successfully applied to improve the dissolution rate …
this work, a nano-cocrystal strategy was successfully applied to improve the dissolution rate …
Formulation and optimization of drug-loaded mesoporous silica nanoparticle-based tablets to improve the dissolution rate of the poorly water-soluble drug silymarin
AH Ibrahim, JH Smått, NP Govardhanam… - European Journal of …, 2020 - Elsevier
… dissolution rate of poorly soluble compounds. The purpose of this study was to enhance the
saturation solubility, dissolution rate … slow dissolution rate due to poor aqueous solubility, as …
saturation solubility, dissolution rate … slow dissolution rate due to poor aqueous solubility, as …
[HTML][HTML] A review on solid dispersion and carriers used therein for solubility enhancement of poorly water soluble drugs
AR Tekade, JN Yadav - Advanced pharmaceutical bulletin, 2020 - ncbi.nlm.nih.gov
… Poor aqueous solubility can leads to failure in formulation development process. The main
reason behind inadequate bioavailability of drug is its low dissolution rate and low solubility …
reason behind inadequate bioavailability of drug is its low dissolution rate and low solubility …
Overview of the manufacturing methods of solid dispersion technology for improving the solubility of poorly water-soluble drugs and application to anticancer drugs
P Tran, YC Pyo, DH Kim, SE Lee, JK Kim, JS Park - Pharmaceutics, 2019 - mdpi.com
… area, leading to higher drug solubility and dissolution rate. Improving wettability and dispersibility
… Most of the anticancer drugs exhibit poor aqueous solubility causes of dissolution limit …
… Most of the anticancer drugs exhibit poor aqueous solubility causes of dissolution limit …
Dissolution kinetics of zinc oxide and its relationship with physicochemical characteristics
D Cardoso, A Narcy, S Durosoy, C Bordes… - Powder Technology, 2021 - Elsevier
… There is a poor characterization of supplemented sources; they are … solubility of feed
compounds, dissolution rate gives a clear impression of the digestion process rather than solubility. …
compounds, dissolution rate gives a clear impression of the digestion process rather than solubility. …
Improvement strategies for the oral bioavailability of poorly water-soluble flavonoids: An overview
J Zhao, J Yang, Y Xie - International journal of pharmaceutics, 2019 - Elsevier
… bioavailability due to their poor aqueous solubility. To address … enhancing their solubility,
dissolution rate and permeability; … probably resulting from their poor solubility, low permeability, …
dissolution rate and permeability; … probably resulting from their poor solubility, low permeability, …
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