Nanonization techniques to overcome poor water-solubility with drugs

FLO Da Silva, MBDF Marques, KC Kato… - Expert opinion on drug …, 2020 - Taylor & Francis
… The poor water solubility can drastically affect the dissolution rate and, together with
presystemic metabolism events, the drug levels absorbed into the systemic circulation could be …

The role of functional excipients in solid oral dosage forms to overcome poor drug dissolution and bioavailability

J Van der Merwe, J Steenekamp, D Steyn, J Hamman - Pharmaceutics, 2020 - mdpi.com
… ) exhibit poor solubility and low dissolution rates in aqueous … low as a result of their poor
solubility properties. In order to … to improve their aqueous solubility and dissolution rates. With …

Eutectic mixtures as an approach to enhance solubility, dissolution rate and oral bioavailability of poorly water-soluble drugs

GC Bazzo, BR Pezzini, HK Stulzer - International Journal of Pharmaceutics, 2020 - Elsevier
… However, many drugs currently used and in development have poor water solubility and
belong to Classes II and IV of the Biopharmaceutical Classification System (BSC), ie, have low …

Overview of nanoparticulate strategies for solubility enhancement of poorly soluble drugs

KU Khan, MU Minhas, SF Badshah, M Suhail, A Ahmad… - Life Sciences, 2022 - Elsevier
… route is poor bioavailability which is due to poor solubility and permeability. Poor soluble …
Enhancement and improvement in solubility and dissolution rate respectively is required for …

[HTML][HTML] A nano-cocrystal strategy to improve the dissolution rate and oral bioavailability of baicalein

J Pi, S Wang, W Li, D Kebebe, Y Zhang, B Zhang… - Asian journal of …, 2019 - Elsevier
… low solubility, dissolution rate and poor oral absorption limit the therapeutic applications. In
this work, a nano-cocrystal strategy was successfully applied to improve the dissolution rate

Formulation and optimization of drug-loaded mesoporous silica nanoparticle-based tablets to improve the dissolution rate of the poorly water-soluble drug silymarin

AH Ibrahim, JH Smått, NP Govardhanam… - European Journal of …, 2020 - Elsevier
dissolution rate of poorly soluble compounds. The purpose of this study was to enhance the
saturation solubility, dissolution rate … slow dissolution rate due to poor aqueous solubility, as …

[HTML][HTML] A review on solid dispersion and carriers used therein for solubility enhancement of poorly water soluble drugs

AR Tekade, JN Yadav - Advanced pharmaceutical bulletin, 2020 - ncbi.nlm.nih.gov
Poor aqueous solubility can leads to failure in formulation development process. The main
reason behind inadequate bioavailability of drug is its low dissolution rate and low solubility

Overview of the manufacturing methods of solid dispersion technology for improving the solubility of poorly water-soluble drugs and application to anticancer drugs

P Tran, YC Pyo, DH Kim, SE Lee, JK Kim, JS Park - Pharmaceutics, 2019 - mdpi.com
… area, leading to higher drug solubility and dissolution rate. Improving wettability and dispersibility
… Most of the anticancer drugs exhibit poor aqueous solubility causes of dissolution limit …

Dissolution kinetics of zinc oxide and its relationship with physicochemical characteristics

D Cardoso, A Narcy, S Durosoy, C Bordes… - Powder Technology, 2021 - Elsevier
… There is a poor characterization of supplemented sources; they are … solubility of feed
compounds, dissolution rate gives a clear impression of the digestion process rather than solubility. …

Improvement strategies for the oral bioavailability of poorly water-soluble flavonoids: An overview

J Zhao, J Yang, Y Xie - International journal of pharmaceutics, 2019 - Elsevier
… bioavailability due to their poor aqueous solubility. To address … enhancing their solubility,
dissolution rate and permeability; … probably resulting from their poor solubility, low permeability, …