Can machine learning predict drug nanocrystals?

Y He, Z Ye, X Liu, Z Wei, F Qiu, HF Li, Y Zheng… - Journal of Controlled …, 2020 - Elsevier
… , the dissolution rate and saturation solubility of hydrophobic drugs increase significantly [7,8].
The improvement of the dissolution rate … hydrophobic drugs with poor water solubility, were …

[HTML][HTML] Novel oral dosage regimen based on self-nanoemulsifying drug delivery systems for codelivery of phytochemicals–Curcumin and thymoquinone

M Alwadei, M Kazi, FK Alanazi - Saudi Pharmaceutical Journal, 2019 - Elsevier
… The major challenges for curcumin is its poor aqueous solubility and erratic oral … good
polydispersity), higher solubility and therefore increased dissolution rate. The representative liquid …

The critical role of passive permeability in designing successful drugs

L Di, P Artursson, A Avdeef, LZ Benet… - …, 2020 - Wiley Online Library
rate from oral modified-release dosage forms.13 The role of solubility and dissolution rate
… doses are low, or compounds have poor solubility where the transporters are not saturated. …

[PDF][PDF] Methods of Dry and Wet Grinding for Nimodipine-HPMC Nanoparticles: Impact on Physical and Chemical Characteristics, Solubility, and Rate of Dissolution

B Kalpanadevi, E Samantha, P Chandrashekar - jcdponline.org
… characteristics, solubility, and dissolving rate of nimodipine … pH 7.2 was used for the
dissolving rate test, and CO2-free … Because of their poor bioavailability, medications in this …

Hot liquid extrusion assisted drug-cyclodextrin complexation: a novel continuous manufacturing method for solubility and bioavailability enhancement of drugs

ASN Manne, AR Hegde, SY Raut, RR Rao… - Drug delivery and …, 2021 - Springer
… is marred by poor solubility of carbamazepine (~ 120 μg/mL) … be ascribed to the slower
dissolution rate of CBZ. Therefore, … in increasing the solubility and dissolution rate of CBZ has …

Dissolution of kraft lignin in alkaline solutions

E Melro, A Filipe, D Sousa, AJM Valente… - International journal of …, 2020 - Elsevier
… effective, its poor solubility in water represents a serious limitation to be considered when
dissolving higher amounts of lignin. Using NaOH and KOH, it is possible to dissolve ca. 40 wt% …

Predicting and testing bioavailability of magnesium supplements

L Blancquaert, C Vervaet, W Derave - Nutrients, 2019 - mdpi.com
poor solubility. The organic sources of magnesium, on the other hand, offer high levels of
solubility, … Dissolution rates expressed as time to release 80% of Mg content and % release of …

Pharmaceutical cocrystallization: polymorphs, salts and cocrystals

AR Choudhury, M Karanam, M Joshi… - … A: Foundations and …, 2021 - journals.iucr.org
… to their poor aqueous solubility and low dissolution rates or high … which also suffers from
poor aqueous solubility, has resulted … , also suffers from poor solubility and dissolution rate. Our …

Formulation and evaluation of cyclodextrin complexes for improved anticancer activity of repurposed drug: Niclosamide

A Lodagekar, RM Borkar, S Thatikonda… - Carbohydrate …, 2019 - Elsevier
… due to its poor aqueous solubility, poor dissolution and inter individual absorption rate. There
… delivery system with improved solubility, dissolution rate and there by bioavailability before …

Formulation, optimization and evaluation of ticagrelor liquisolid tablets for enhanced solubility

U Shastri, KP Sutar, VA Jadhav… - Research Journal of …, 2024 - indianjournals.com
… to poor aqueous solubility and restricted intestinal permeability, ultimately leading to poor
Ticagrelor's therapeutic performance and dissolution rate using the liquisolid compact …