DNA methylation disruption reshapes the hematopoietic differentiation landscape
Mutations in genes involved in DNA methylation (DNAme; for example, TET2 and DNMT3A)
are frequently observed in hematological malignancies 1 , 2 – 3 and clonal hematopoiesis 4 …
are frequently observed in hematological malignancies 1 , 2 – 3 and clonal hematopoiesis 4 …
Simultaneous profiling of chromatin accessibility and methylation on human cell lines with nanopore sequencing
… CpG methylation and chromatin accessibility simultaneously on long strands of DNA by …
-specific profiles of DNA methylation and accessibility on a human genome. We compared …
-specific profiles of DNA methylation and accessibility on a human genome. We compared …
Interplay between chromatin marks in development and disease
SM Janssen, MC Lorincz - Nature Reviews Genetics, 2022 - nature.com
… Of note, in Dnmt3a;Dnmt3b double-knockout (DKO) oocytes, H3K4me3 expands into non-promoter
regions that are normally de novo DNA methylated, indicating that DNAme may …
regions that are normally de novo DNA methylated, indicating that DNAme may …
[PDF][PDF] G9a plays distinct roles in maintaining DNA methylation, retrotransposon silencing, and chromatin looping
… DNA methylation loss in G9a depleted and catalytic mutant embryonic stem cells. Furthermore,
we define how G9a regulates chromatin … G9a leads to altered chromatin states, aberrant …
we define how G9a regulates chromatin … G9a leads to altered chromatin states, aberrant …
Regenerating zebrafish fin epigenome is characterized by stable lineage-specific DNA methylation and dynamic chromatin accessibility
… We produce epigenome maps, including DNA methylation and chromatin accessibility…
chromatin accessibility changes, coupled with stably maintained lineage-specific DNA methylation…
chromatin accessibility changes, coupled with stably maintained lineage-specific DNA methylation…
[HTML][HTML] Toward a mechanistic understanding of DNA methylation readout by transcription factors
… the confounded effects of DNA modification on TF binding, chromatin accessibility, … DNA
interactions has enabled comprehensive characterization and quantification of the methylation …
interactions has enabled comprehensive characterization and quantification of the methylation …
Longitudinal genome-wide DNA methylation analysis uncovers persistent early-life DNA methylation changes
RF Pérez, P Santamarina, JR Tejedor… - Journal of translational …, 2019 - Springer
… We found abundant DNA methylation changes (110,726 CpG … However, our analysis revealed
persistent DNA methylation … DNA methylation and chromatin levels [6] and precise DNA …
persistent DNA methylation … DNA methylation and chromatin levels [6] and precise DNA …
Interactions between core histone marks and DNA methyltransferases predict DNA methylation patterns observed in human cells and tissues
K Fu, G Bonora, M Pellegrini - Epigenetics, 2020 - Taylor & Francis
… methylation, indicating a more complex interaction with DNA methylation than that found
in other chromatin … between DNA methylation, histone modifications and chromatin states …
in other chromatin … between DNA methylation, histone modifications and chromatin states …
DNA methylation analysis
L Feng, J Lou - Nanotoxicity: Methods and Protocols, 2019 - Springer
… , transcriptional regulation, and chromatin remodeling. Profiling DNA methylation across
the genome is critical to understanding the influence of methylation in normal biology and …
the genome is critical to understanding the influence of methylation in normal biology and …
Kinetics and mechanisms of mitotic inheritance of DNA methylation and their roles in aging-associated methylome deterioration
… Although nucleosomes offer multiple mechanisms to interact with and even stimulate the
maintenance machinery, 20 chromatin likely acts as a barrier to DNA methylation. …
maintenance machinery, 20 chromatin likely acts as a barrier to DNA methylation. …