DNA methylation dynamics during germline development

S He, X Feng - Journal of Integrative Plant Biology, 2022 - Wiley Online Library
… In animals, DNA methylation is also developmentally … the understanding that DNA methylation
plays a similar role in … dynamic changes in DNA methylation during germline development. …

The diverse roles of DNA methylation in mammalian development and disease

MVC Greenberg, D Bourc'his - Nature reviews Molecular cell biology, 2019 - nature.com
… We highlight the dynamic erasure and re-establishment of DNA methylation in embryonic,
germline and somatic cell development. Finally, we provide insights into DNA methylation

DNA methylation in the vertebrate germline: balancing memory and erasure

O Ortega-Recalde, TA Hore - Essays in biochemistry, 2019 - portlandpress.com
… defined germline of chicken to preserve DNA methylation in PGCs, but that salamanders
and axolotls show epigenetic erasure on account of their germline defined by induction [104]. …

The impact of DNA methylation dynamics on the mutation rate during human germline development

Y Zhou, F He, W Pu, X Gu, J Wang… - G3: Genes, Genomes …, 2020 - academic.oup.com
… Our study provides evidence that DNA methylation in germline relevant cells has a … DNA
methylation levels mentioned in this study are specifically referred to as the DNA methylation

DNA methylation dynamics in the female germline and maternal-effect mutations that disrupt genomic imprinting

Z Anvar, I Chakchouk, H Demond, M Sharif, G Kelsey… - Genes, 2021 - mdpi.com
… key milestones in DNA methylation patterning in the female germline and the embryo focusing
on humans. We provide an overview of recent findings regarding DNA methylation deficits …

Maternal vitamin C regulates reprogramming of DNA methylation and germline development

SP DiTroia, M Percharde, MJ Guerquin, E Wall… - Nature, 2019 - nature.com
… acid) in the developing germline, which expresses high … test the role of vitamin C in germline
development (see Methods). … of global DNA methylation during germline reprogramming 3 …

Zebrafish preserve global germline DNA methylation while sex-linked rDNA is amplified and demethylated during feminisation

O Ortega-Recalde, RC Day, NJ Gemmell… - Nature …, 2019 - nature.com
DNA methylation dynamics in the zebrafish germline throughout development. In stark
contrast to mammals, we find DNA methylation is not erased at any stage of germlinegermline

DNA methylation from germline cells in veterans with PTSD

D Mehta, ES Pelzer, D Bruenig, B Lawford… - Journal of psychiatric …, 2019 - Elsevier
… 7 DNA methylation in Holocaust survivors and significantly lower FKBP5 intron 7 DNA methylation
in their … These findings suggest that trauma-induced DNA methylation changes can be …

DNA methylation reprogramming during mammalian development

Y Zeng, T Chen - Genes, 2019 - mdpi.com
… patterns, transcription profiles, and chromatin modifications, including silencing of pluripotency
genes and germline-specific genes by DNA methylation [7]. At this point, PGCs display …

Repression of germline genes by PRC1. 6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencing

K Mochizuki, J Sharif, K Shirane, K Uranishi… - Nature …, 2021 - nature.com
Silencing of a subset of germline genes is dependent upon DNA methylation (DNAme) post-implantation.
However, these genes are generally hypomethylated in the blastocyst, …