DNA methylation dynamics during germline development
… In animals, DNA methylation is also developmentally … the understanding that DNA methylation
plays a similar role in … dynamic changes in DNA methylation during germline development. …
plays a similar role in … dynamic changes in DNA methylation during germline development. …
The diverse roles of DNA methylation in mammalian development and disease
MVC Greenberg, D Bourc'his - Nature reviews Molecular cell biology, 2019 - nature.com
… We highlight the dynamic erasure and re-establishment of DNA methylation in embryonic,
germline and somatic cell development. Finally, we provide insights into DNA methylation …
germline and somatic cell development. Finally, we provide insights into DNA methylation …
DNA methylation in the vertebrate germline: balancing memory and erasure
O Ortega-Recalde, TA Hore - Essays in biochemistry, 2019 - portlandpress.com
… defined germline of chicken to preserve DNA methylation in PGCs, but that salamanders
and axolotls show epigenetic erasure on account of their germline defined by induction [104]. …
and axolotls show epigenetic erasure on account of their germline defined by induction [104]. …
The impact of DNA methylation dynamics on the mutation rate during human germline development
Y Zhou, F He, W Pu, X Gu, J Wang… - G3: Genes, Genomes …, 2020 - academic.oup.com
… Our study provides evidence that DNA methylation in germline relevant cells has a … DNA
methylation levels mentioned in this study are specifically referred to as the DNA methylation …
methylation levels mentioned in this study are specifically referred to as the DNA methylation …
DNA methylation dynamics in the female germline and maternal-effect mutations that disrupt genomic imprinting
… key milestones in DNA methylation patterning in the female germline and the embryo focusing
on humans. We provide an overview of recent findings regarding DNA methylation deficits …
on humans. We provide an overview of recent findings regarding DNA methylation deficits …
Maternal vitamin C regulates reprogramming of DNA methylation and germline development
SP DiTroia, M Percharde, MJ Guerquin, E Wall… - Nature, 2019 - nature.com
… acid) in the developing germline, which expresses high … test the role of vitamin C in germline
development (see Methods). … of global DNA methylation during germline reprogramming 3 …
development (see Methods). … of global DNA methylation during germline reprogramming 3 …
Zebrafish preserve global germline DNA methylation while sex-linked rDNA is amplified and demethylated during feminisation
… DNA methylation dynamics in the zebrafish germline throughout development. In stark
contrast to mammals, we find DNA methylation is not erased at any stage of germline … germline …
contrast to mammals, we find DNA methylation is not erased at any stage of germline … germline …
DNA methylation from germline cells in veterans with PTSD
… 7 DNA methylation in Holocaust survivors and significantly lower FKBP5 intron 7 DNA methylation
in their … These findings suggest that trauma-induced DNA methylation changes can be …
in their … These findings suggest that trauma-induced DNA methylation changes can be …
DNA methylation reprogramming during mammalian development
Y Zeng, T Chen - Genes, 2019 - mdpi.com
… patterns, transcription profiles, and chromatin modifications, including silencing of pluripotency
genes and germline-specific genes by DNA methylation [7]. At this point, PGCs display …
genes and germline-specific genes by DNA methylation [7]. At this point, PGCs display …
Repression of germline genes by PRC1. 6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencing
K Mochizuki, J Sharif, K Shirane, K Uranishi… - Nature …, 2021 - nature.com
Silencing of a subset of germline genes is dependent upon DNA methylation (DNAme) post-implantation.
However, these genes are generally hypomethylated in the blastocyst, …
However, these genes are generally hypomethylated in the blastocyst, …
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