DNA methylation clocks and their predictive capacity for aging phenotypes and healthspan
T Bergsma, E Rogaeva - Neuroscience insights, 2020 - journals.sagepub.com
… mechanism, which implicated 59 genes as modulators of age-related behavioural deterioration
rate. … , the most promising are based on the DNA methylation (DNAm) of cytosines at CpG …
rate. … , the most promising are based on the DNA methylation (DNAm) of cytosines at CpG …
Dynamic enhancer DNA methylation as basis for transcriptional and cellular heterogeneity of ESCs
Y Song, PR van den Berg, S Markoulaki, F Soldner… - Molecular cell, 2019 - cell.com
… DNA methylation state is dynamically switching, resulting in cell-to-cell heterogeneity. Dynamic
DNA methylation is driven by the balance between DNA … DNA methylation at the Sox2 …
DNA methylation is driven by the balance between DNA … DNA methylation at the Sox2 …
Enzymatic methyl sequencing detects DNA methylation at single-base resolution from picograms of DNA
R Vaisvila, VKC Ponnaluri, Z Sun… - Genome …, 2021 - genome.cshlp.org
… In contrast, EM-seq libraries display little to no DNA damage and have few biases associated
with it. This, combined with accurate DNA methylation calls, enhances the potential of EM-…
with it. This, combined with accurate DNA methylation calls, enhances the potential of EM-…
MiR-29a inhibits invasion and metastasis of cervical cancer via modulating methylation of tumor suppressor SOCS1
Y Gong, JH Wan, W Zou, GY Lian, JL Qin… - Future …, 2019 - Taylor & Francis
… We also found relatively higher DNA methylation level of SOCS1 gene promoter region in
Siha and Hela cell lines, comparing with Caski ( Figure 2B ). Similar results were obtained …
Siha and Hela cell lines, comparing with Caski ( Figure 2B ). Similar results were obtained …
Health-promoting role of dietary bioactive compounds through epigenetic modulations: a novel prophylactic and therapeutic approach
… in gene expression through alterations in DNA methylation, histone modifications and …
γ-synuclein (SNCG) by modulating DNA promoter methylation through the action of DNMT3 and …
γ-synuclein (SNCG) by modulating DNA promoter methylation through the action of DNMT3 and …
Curcumin reinforces MSC‐derived exosomes in attenuating osteoarthritis via modulating the miR‐124/NF‐kB and miR‐143/ROCK1/TLR9 signalling pathways
B Qiu, X Xu, P Yi, Y Hao - Journal of Cellular and Molecular …, 2020 - Wiley Online Library
… This study demonstrated that curcumin treatment decreased the DNA methylation of miR-143
and miR-124 promoters. As a result, miR-143 and miR-124 were up-regulated to further …
and miR-124 promoters. As a result, miR-143 and miR-124 were up-regulated to further …
[HTML][HTML] The emerging molecular mechanism of m6A modulators in tumorigenesis and cancer progression
S Liu, Q Li, K Chen, Q Zhang, G Li, L Zhuo… - Biomedicine & …, 2020 - Elsevier
… Intriguingly, BH promotes the splicing of Suv39H1 through enhancement of m 6 A RNA
methylation rather than DNA methylation, which has been reported to induce the pattern of …
methylation rather than DNA methylation, which has been reported to induce the pattern of …
Identification of DNA methylation patterns predisposing for an efficient response to BCG vaccination in healthy BCG-naïve subjects
… DNA methylation is one of the most studied epigenetic … microbial components evokes
modulation at the epigenomic … showed an altered DNA methylation pattern enriched in immune …
modulation at the epigenomic … showed an altered DNA methylation pattern enriched in immune …
Cytosine-based TET enzyme inhibitors
GNL Chua, KL Wassarman, H Sun, JA Alp… - ACS medicinal …, 2019 - ACS Publications
… DNA methylation patterns tend to be maintained in differentiated cells; however, the … several
cancer states as well as in the modulation of neuronal plasticity and memory. As there does …
cancer states as well as in the modulation of neuronal plasticity and memory. As there does …
Altered DNA methylation underlies monocyte dysregulation and innate exhaustion memory in sepsis
… in exhausted monocytes, greatly limiting the number of hypermethylated regions observed
in these cells and restoring 5mC levels at regulatory sites for critical immune modulators such …
in these cells and restoring 5mC levels at regulatory sites for critical immune modulators such …