Circulating tumor DNA methylation profiles enable early diagnosis, prognosis prediction, and screening for colorectal cancer

H Luo, Q Zhao, W Wei, L Zheng, S Yi, G Li… - Science translational …, 2020 - science.org
… CRC tissue DNA methylation data from TCGA and normal blood leukocyte methylation data
… in sample types might increase data deviation in marker screening. Second, this was not a …

[HTML][HTML] DNA methylation biomarkers in stool for early screening of colorectal cancer

J Chen, H Sun, W Tang, L Zhou, X Xie, Z Qu… - Journal of …, 2019 - ncbi.nlm.nih.gov
… and verify that detecting DNA methylation of genes in stool could reveal biomarkers for early
detection of CRC. We examined the associations between the methylation status of NDRG4…

DNA methylation analysis for screening and diagnostic testing in neurodevelopmental disorders

DE Godler, DJ Amor - Essays in Biochemistry, 2019 - portlandpress.com
DNA methylation is the process where methyl groups are added to DNA molecules which
changes the activity of the DNADNA methylation in cancer, the role of DNA methylation in the …

DNA methylation cancer biomarkers: translation to the clinic

WJ Locke, D Guanzon, C Ma, YJ Liew… - Frontiers in …, 2019 - frontiersin.org
DNA methylation cancer biomarkers used in clinical practice across the application domains
above, discuss what makes a suitable DNA methylation … with traditional screening and …

Multiplex methylated DNA testing in plasma with high sensitivity and specificity for colorectal cancer screening

G Zhao, H Li, Z Yang, Z Wang, M Xu, S Xiong… - Cancer …, 2019 - Wiley Online Library
… method need to be developed to promote early CRC screening. DNA methylation, the addition
of methyl groups to the cytosine residues of DNA, is a form of epigenetic modification that …

Diagnostic utility of genome-wide DNA methylation testing in genetically unsolved individuals with suspected hereditary conditions

E Aref-Eshghi, EG Bend, S Colaiacovo… - The American Journal of …, 2019 - cell.com
… of genome-wide DNA methylation analysis of peripheral blood … of 14 syndromes using DNA
methylation data with full accuracy. … This study demonstrates that genomic DNA methylation

DNA methylation-based testing in liquid biopsies as detection and prognostic biomarkers for the four major cancer types

V Constâncio, SP Nunes, R Henrique, C Jerónimo - Cells, 2020 - mdpi.com
… Even though numerous studies report the feasibility of DNA methylation to detect BrC, its …
Nonetheless, DNA methylation shows promise to complement BrC standard screening and …

Novel DNA methylation biomarkers show high sensitivity and specificity for blood-based detection of colorectal cancer—a clinical biomarker discovery and validation …

SØ Jensen, N Øgaard, MBW Ørntoft, MH Rasmussen… - Clinical …, 2019 - Springer
… CRC screening has proven efficient for early detection of cancerous lesions, but current
screening strategies suffer from low compliance rates. Here, we report the identification of three …

A panel of DNA methylation biomarkers for detection and improving diagnostic efficiency of lung cancer

B Wei, F Wu, W Xing, H Sun, C Yan, C Zhao… - Scientific Reports, 2021 - nature.com
… Extensive prospective screening trials have … , methylation assays are relatively easy to set
up, perform, and automate. This study demonstrated that the assessment of DNA methylation

Performance of DNA methylation assays for detection of high-grade cervical intraepithelial neoplasia (CIN2+): a systematic review and meta-analysis

H Kelly, Y Benavente, MA Pavon, S De Sanjose… - British journal of …, 2019 - nature.com
… within biopsy specimens were excluded as we aimed to evaluate the performance of DNA
methylation assays as a potential primary screening or triage tests when cervical swabs would …