Anatomy of DNA methylation signatures: Emerging insights and applications

E Chater-Diehl, SJ Goodman, C Cytrynbaum… - The American Journal of …, 2021 - cell.com
DNA methylation (DNAm) signatures are unique patterns of DNAm alterations defined for
rare … cause a distinct neurodevelopmental disorder with a specific DNA methylation signature. …

DNA methylation signatures of incident coronary heart disease: findings from epigenome-wide association studies

Y Xia, A Brewer, JT Bell - Clinical Epigenetics, 2021 - Springer
… review explores DNA methylation signatures of iCHD, … DNA methylation information for
the risk assessment of iCHD, as well as to improve our understanding of how DNA methylation

Deciphering DNA methylation signatures of pancreatic cancer and pancreatitis

F Natale, M Vivo, G Falco, T Angrisano - Clinical Epigenetics, 2019 - Springer
DNA methylation was, on average, 50% more frequent in PTs. Only for EFNA4, BTBD6, and
FZD2-7 DNA methylation … biomarkers showing PT-specific DNA methylation signatures [65]. …

DNA methylation signatures for chromatinopathies: current challenges and future applications

Z Awamleh, S Goodman, S Choufani, R Weksberg - Human Genetics, 2024 - Springer
… In this perspective, we describe the seminal DNA methylation signature research in … ,
phenotype and DNA methylation, and the future applications of DNA methylation signatures. …

Novel DNA methylation signatures of tobacco smoking with trans-ethnic effects

C Christiansen, JE Castillo-Fernandez… - Clinical …, 2021 - Springer
… and DNA methylation levels … DNA methylation levels between current and never smokers
in a cross-sectional analysis to identify novel smoking-associated differentially methylated

Blood-derived DNA methylation signatures of Crohn's disease and severity of intestinal inflammation

HK Somineni, S Venkateswaran, V Kilaru… - Gastroenterology, 2019 - Elsevier
… To evaluate the potential impact of therapy on the reversal of Crohn's disease–associated
methylation signatures, we stratified patients based on the class of medications they were …

Prognostic and predictive value of three DNA methylation signatures in lung adenocarcinoma

Y Wang, H Deng, S Xin, K Zhang, R Shi, X Bao - Frontiers in genetics, 2019 - frontiersin.org
… Based on DNA methylation patterns, machine learning … the possibility of DNA methylation
signatures in identifying … TCGA whole-genome methylation datasets to several machine …

A DNA methylation signature to improve survival prediction of gastric cancer

Y Peng, Q Wu, L Wang, H Wang, F Yin - Clinical epigenetics, 2020 - Springer
… This study presents a powerful DNA methylation signature by … The identified DNA methylation
signature may be used to … individual genes of the DNA methylation signature. Also, clinical …

A genome-wide DNA methylation signature for SETD1B-related syndrome

IM Krzyzewska, SM Maas, P Henneman, K Lip… - Clinical …, 2019 - Springer
… Examination of the specificity of the SETD1B-related DNAm signature We examined whether
the DNA methylation signature of SETD1B-related syndrome overlaps with that of other …

[HTML][HTML] DNA methylation signatures reveal that distinct combinations of transcription factors specify human immune cell epigenetic identity

R Roy, S Ramamoorthy, BD Shapiro, M Kaileh… - Immunity, 2021 - cell.com
… Here, we identified lineage-specific DNA methylation signatures of six immune cell types …
cell types, suggesting that it regulates DNA methylation in a context-dependent manner. These …