Association of peripheral blood DNA methylation level with Alzheimer's disease progression

…, Alzheimer's Disease Neuroimaging Initiative (ADNI) - Clinical …, 2021 - Springer
model (robust regression), which is different from the nonlinear trajectory of cognitive decline
previously proposed in a hypothetical model … recall, Alzheimer Disease Assessment Scale-…

DNA methylation in the pathology of Alzheimer's disease: from gene to cognition

CH Poon, LSR Tse, LW Lim - Annals of the New York Academy …, 2020 - Wiley Online Library
… Although this study was conducted in a stress animal model, it still provides evidence from
an epigenetic perspective for NPAS4 as a possible target. Another molecule involved in tau …

DNA methylation variability in Alzheimer's disease

Z Huo, Y Zhu, L Yu, J Yang, P De Jager, DA Bennett… - Neurobiology of …, 2019 - Elsevier
… we fitted a logistic regression model, in which methylation variability status (hypervariable or
… We found that the observed differential association of DNA methylation variability status with …

Harnessing peripheral DNA methylation differences in the Alzheimer's Disease Neuroimaging Initiative (ADNI) to reveal novel biomarkers of disease

…, Alzheimer's Disease Neuroimaging Initiative (ADNI) - Clinical …, 2020 - Springer
… We analyzed differential DNA methylation across diagnosis groups using a mixed model
with a … Data collection and sharing for this project was funded by the Alzheimer's Disease

Prediction of Alzheimer's disease based on deep neural network by integrating gene expression and DNA methylation dataset

C Park, J Ha, S Park - Expert Systems with Applications, 2020 - Elsevier
… We present a novel Alzheimer's disease prediction model based on deep neural network. …
based model that can predict AD using large-scale gene expression and DNA methylation data…

DNA methylation in APOE: The relationship with Alzheimer's and with cardiovascular health

J Mur, DL McCartney, RM Walker… - Alzheimer's & …, 2020 - Wiley Online Library
… We assessed blood-based DNA methylation at 13 CpGs in the … Using linear mixed models
regression, we examined the … risks of Alzheimer's disease (AD) and cardiovascular disease. …

Integrated DNA methylation and gene expression profiling across multiple brain regions implicate novel genes in Alzheimer's disease

SA Semick, RA Bharadwaj, L Collado-Torres… - Acta …, 2019 - Springer
… To assess whether regions of the genome were differentially methylated between Alzheimer’s
disease cases and controls, we used bumphunter with the same models as above [26]. …

Epigenome-wide meta-analysis of DNA methylation differences in prefrontal cortex implicates the immune processes in Alzheimer's disease

L Zhang, TC Silva, JI Young, L Gomez… - Nature …, 2020 - nature.com
… utility of DNA methylation as clinical biomarkers, we also compared methylation differences
in … , we first removed confounding effects in DNA methylation data by fitting the model median …

Sex-specific DNA methylation differences in Alzheimer's disease pathology

L Zhang, JI Young, L Gomez, TC Silva… - Acta neuropathologica …, 2021 - Springer
… in DNA methylation data by fitting the model methylation M … from this model; these are the
ROSMAP methylation residuals. … ] that are annotated to Alzheimer's disease, many of which are …

DNA methylation: a promising approach in management of Alzheimer's disease and other neurodegenerative disorders

G Kaur, SSS Rathod, MM Ghoneim, S Alshehri… - Biology, 2022 - mdpi.com
… , we summarize the association of DNA methylation with the … diseases, such as, Alzheimer’s
disease, Parkinson’s disease, … model, as well as in the 3xTg-AD mouse model, changes in …