[HTML][HTML] A randomized clinical study (SEECASE) to assess efficacy, safety, and tolerability of NOV03 for treatment of dry eye disease

J Tauber, DL Wirta, K Sall, PA Majmudar, D Willen… - Cornea, 2021 - journals.lww.com
… Blurred vision in the NOV03 QID group, eye irritation in the NOV03 BID group, and eye
pain in the saline group were the only terms reported by more than 2% of subjects (2.6%–2.7%). …

[HTML][HTML] Safety and efficacy of twice daily administration of KPI-121 1% for ocular inflammation and pain following cataract surgery

T Kim, K Sall, EJ Holland, RK Brazzell… - Clinical …, 2019 - ncbi.nlm.nih.gov
… research was to investigate the efficacy and safety of a twice daily (BID) … safety and efficacy
of KPI-121 1% to vehicle in the treatment of subjects with postsurgical inflammation and pain

[HTML][HTML] Efficacy of topical ophthalmic drugs in the treatment of dry eye disease: A systematic literature review

EJ Holland, M Darvish, KK Nichols, L Jones… - The Ocular Surface, 2019 - Elsevier
… In a large dose-response phase 2 study, the efficacy and safety of 1% and 2% rebamipide
… and TBUT, foreign body sensation and eye pain scores were significantly improved in the …

[HTML][HTML] Efficacy and safety of a novel naltrexone treatment for dry eye in type 1 diabetes

PJ McLaughlin, JW Sassani, MB Titunick, IS Zagon - BMC ophthalmology, 2019 - Springer
… This study examined the safety and efficacy of a proprietary new eye drop formulation for …
-Dawley rats to study the efficacy and safety of the investigational compound that contained 20 …

[HTML][HTML] Efficacy and tolerability of nortriptyline in the management of neuropathic corneal pain

MC Ozmen, G Dieckmann, SM Cox, R Rashad… - The ocular …, 2020 - Elsevier
… the efficacyeye pain in the past 24 h on a scale of 0–10 at the visit where nortriptyline was
prescribed (termed “first visit” for the purposes of this study); 3) the average level of eye pain

Evaluation of the safety and efficacy of intense pulsed light treatment with meibomian gland expression of the upper eyelids for dry eye disease

R Toyos, M Toyos, J Willcox, H Mulliniks… - … , and Laser Surgery, 2019 - liebertpub.com
… the safety of and change from baseline of tear breakup time and visual analog pain scales in
dry eye … assessing global ocular pain severity, ocular pain frequency, and ocular pain in the …

[HTML][HTML] Randomized, controlled, double-masked, multicenter, pilot study evaluating safety and efficacy of intranasal neurostimulation for dry eye disease

GS Cohn, D Corbett, A Tenen… - … & Visual Science, 2019 - iovs.arvojournals.org
… the safety and effectiveness of intranasal neurostimulation to promote tear production via the
nasolacrimal pathway in subjects with dry eye … The significant improvement in ocular pain

[HTML][HTML] Selective pharmacologic therapies for dry eye disease treatment: efficacy, tolerability, and safety data review from preclinical studies and pivotal trials

B Shen Lee, M Toyos, P Karpecki, J Schiffbauer… - Ophthalmology and …, 2022 - Springer
Eye irritation and eye pain were the most common TEAEs in the CsA CE 0.1% and vehicle …
Instillation site pain was the most frequently reported treatment-related ocular AE in SANSIKA …

[HTML][HTML] A clinical phase II study to assess efficacy, safety, and tolerability of waterfree cyclosporine formulation for treatment of dry eye disease

DL Wirta, GL Torkildsen, HR Moreira, JD Lonsdale… - Ophthalmology, 2019 - Elsevier
… CyclASol showed efficacy, safety, and tolerability at 2 concentrations in moderate-to-severe …
in dry eye sufferers, was shown to have the most benefit from treatment. Excellent safety, …

Efficacy and safety of 0.1% ciclosporin A cationic emulsion in dry eye disease: a pooled analysis of two double-masked, randomised, vehicle-controlled phase III …

A Leonardi, EM Messmer, M Labetoulle… - British Journal of …, 2019 - bjo.bmj.com
… A composite responder efficacy endpoint (corneal fluorescein staining–Ocular Surface
Disease Index (CFS–OSDI) at month 6) was used to evaluate the efficacy of CsA CE in alleviating …