Treatment of non-small cell lung cancer with EGFR-mutations

K Yoneda, N Imanishi, Y Ichiki, F Tanaka - Journal of UOEH, 2019 - jstage.jst.go.jp
… the tyrosine kinase of EGFR, which competitively inhibits ATP-… lung adenocarcinoma with
EGFRmutations (overall response rate [ORR], 71.2%), but not for that without EGFR-mutations (…

[HTML][HTML] Treatment of uncommon EGFR mutations in non-small cell lung cancer: new evidence and treatment

T Zhang, B Wan, Y Zhao, C Li, H Liu, T Lv… - … lung cancer research, 2019 - ncbi.nlm.nih.gov
… In China, it is also the most common cancer and leading cause of cancer-related … (EGFR)
mutations. NSCLC harboring EGFR mutations constitutes about 10–20% of all lung cancer

[HTML][HTML] Rare epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer

PT Harrison, S Vyse, PH Huang - Seminars in cancer biology, 2020 - Elsevier
EGFR mutations in patients, our understanding of the biology of these … EGFR mutations is
poor compared to classical mutations. In particular, clinical data focused on these mutations is …

Clinical significance of EGFR mutation types in lung adenocarcinoma: A multi-centre Korean study

HY Yoon, JS Ryu, YS Sim, D Kim, SY Lee, J Choi… - PLoS …, 2020 - journals.plos.org
mutation. In conclusion, the presence of EGFR mutations in advanced lung adenocarcinoma
… prognosis than other mutations, while an E21 mutation is expected to increase mortality. …

Predicting EGFR mutation status in lung adenocarcinoma on computed tomography image using deep learning

S Wang, J Shi, Z Ye, D Dong, D Yu… - European …, 2019 - Eur Respiratory Soc
… learning model to predict EGFR mutation status in lung adenocarcinoma using non-invasive …
from 844 lung adenocarcinoma patients with pre-operative CT images, EGFR mutation and …

Paired genomic analysis of squamous cell carcinoma transformed from EGFR-mutated lung adenocarcinoma

S Park, JH Shim, B Lee, I Cho, WY Park, Y Kim, SH Lee… - Lung Cancer, 2019 - Elsevier
Adenocarcinoma (ADC) to squamous cell carcinoma (SCC) … factor receptor (EGFR)-mutated
non–small cell lung cancer after … lung cancer (SCC) transformation (AST) in EGFR-mutated

[HTML][HTML] Osimertinib in Resected EGFR-Mutated Non–Small-Cell Lung Cancer

YL Wu, M Tsuboi, J He, T John, C Grohe… - … England Journal of …, 2020 - Mass Medical Soc
Background Osimertinib is standard-of-care therapy for previously untreated epidermal
growth factor receptor (EGFR) mutation–positive advanced non–small-cell lung cancer (NSCLC). …

EGFR-Mutated Squamous Cell Lung Cancer and Its Association With Outcomes

R Jin, L Peng, J Shou, J Wang, Y Jin, F Liang… - Frontiers in …, 2021 - frontiersin.org
lung SCC patients with EGFR mutations, and enrolled patients with EGFR-mutant
adenocarcinoma and EGFR … patterns of EGFR-mutant SCC, and analyze EGFR-TKI efficacy in …

[HTML][HTML] EGFR mutation subtypes and response to immune checkpoint blockade treatment in non-small-cell lung cancer

K Hastings, HA Yu, W Wei, F Sanchez-Vega… - Annals of …, 2019 - Elsevier
… The results of this study suggest that EGFR mutant subtypes of non-small-cell lung cancer
have distinct response to immune checkpoint inhibitors and distinct tumor mutation burdens. …

Clinical impacts of EGFR mutation status: analysis of 5780 surgically resected lung cancer cases

…, Japanese Joint Committee of Lung Cancer … - The Annals of thoracic …, 2021 - Elsevier
lung cancer included in this study, 5780 patients (41.0%) had been tested for EGFR mutation
… advanced disease were more likely to be tested for EGFR mutation status (Figure 1A). In …