… liquid biopsies of resistant patients reveal … in mechanisms of resistance to 3rd‑generation
EGFR‑TKIs in advanced NSCLC, and provides possible strategies to overcome this resistance. …

… of resistance to such TKI inevitably occurs. The identification of these resistances remains …
the literature about molecular mechanisms of EGFR-TKI resistance in EGFR-mutated NSCLC, …

… Tumor resistance to EGFR tyrosine kinase inhibitors (TKIs) occurs invariably, and receptor
… of EGFR TKIs remain in use. Other major resistance mechanisms to EGFR TKIs are MET …

… mediated resistance contributes to improving the benefit of TKI treatment for NSCLC patients.
In this review, we focus on potential mechanisms of acquired EGFR-TKI resistance induced …

… mechanisms of EGFR-TKI resistance. Below, we describe the acquired resistance mechanisms
to EGFR-TKIs … into EGFR-dependent due to the insurgence of new EGFR mutations and …

Simple Summary Resistance to tyrosine kinase inhibitors (TKIs) of the epidermal growth
factor receptor (EGFR) in advanced mutant non-small cell lung cancer (NSCLC) constitutes a …

… the majority of resistance to first-generation EGFR TKIs [150]. The most common mechanism
of resistance entails appearance of a secondary mutation (T790M) in the EGFR’s kinase …

… Whether the combination of angiogenesis inhibitors and EGFR-TKIs modifies the
resistance mechanism is a subject for further investigation. The mechanisms of resistance to …

… , new EGFR mutations, as well as additional drug-resistance mechanisms emerge rapidly
after … the molecular mechanisms underlying resistance to third-generation EGFR inhibitors and …

… mechanisms of EGFR mutation-based resistance and evolution. Update the clinical progress
and promising directions for novel drug development of overcoming EGFR TKIs resistance. …