… genetics and epigenetics in cancer can be bidirectional 1 . In terms of DNA methylation,
tumours frequently show a global loss of DNA methylation 3 with gains of focal DNA methylation …

… , several driver mutations in leukemic pathogenesis have been identified in genes that
affect epigenetic processes, such as DNA methylation and histone acetylation. Several …

… Thus, epigenetic therapies controlling autoimmunity and systemic inflammation may find …
targeting DNA methylation may improve diagnostic, prognostic, and therapeutic approaches. …

… The epigenetic modification DNA methylation regulates gene expression through the addition
of a methyl group to promoter regions of DNA to … Aberrant DNA methylation and structural …

… DNA methylation in the development of tumors. DNA methylation (DNAm) is an epigenetic
change that promotes the covalent transfer of methyl groups to DNA. This process suppresses …

… The disruption of normal epigenetic mechanisms, namely, DNA methylation, is a known … of
aberrant DNA methylation in BC, focusing on therapeutic strategies that target this epigenetic …

… inhibit the maintenance and acquisition of DNA methylation and reactivate gene expression
14 . … Since a primary mechanism of action of epigenetic therapies is to induce transcriptional …

… is embryonically lethal because DNA methylation patterns are … DNA methylation has evolved
from one in which methylation … braoder perspective where DNA methylation is dynamically …

… methyltransferases (DNMTs) to specific genomic loci to promote DNA methylation [19,… DNA
methylation and histone modification machinery critical for maintaining the cellular epigenetic …

… Epigenetic modifications, including DNA methylation and demethylation and histone … -cancer
therapy given the reversible nature of epigenetic changes. Hence, epigenetic therapy has …