[HTML][HTML] Estrogen receptors in colorectal cancer: Facts, novelties and perspectives

I Ditonno, G Losurdo, M Rendina, M Pricci, B Girardi… - Current …, 2021 - mdpi.com
… by treating HCT116 colon cancer cells with ERβ gene constructed into adenoviral vectors
alone or in combination with raloxifene, a selective estrogen receptor modulator. Only the …

Targeting estrogen receptors in colorectal cancer

JW Maingi, S Tang, S Liu, W Ngenya, E Bao - Molecular Biology Reports, 2020 - Springer
… Abnormal estrogen receptor signaling may increase the risk of development of a variety
of … Estrogen receptor beta (ERβ) is the predominant subtype in the colonic epithelium and …

Estrogen receptor alpha regulates the Wnt/β-catenin signaling pathway in colon cancer by targeting the NOD-like receptors

S Liu, W Fan, X Gao, K Huang, C Ding, G Ma, L Yan… - Cellular signalling, 2019 - Elsevier
… in colon carcinoma cell by inhibited NLRP3 expression. In short, the research
demonstrates that NLRs are potential biomarkers for cancer, and ERs can regulate the Wnt/β-catenin …

[HTML][HTML] G protein-coupled estrogen receptor in colon function, immune regulation and carcinogenesis

D Jacenik, EJ Beswick, WM Krajewska… - World Journal of …, 2019 - ncbi.nlm.nih.gov
… α and β, as well as the membrane-bound G protein-coupled estrogen receptor (GPER). The
… GPER in the colon have shown that this estrogen receptor regulates colonic motility as well …

[HTML][HTML] The roles of estrogen and estrogen receptors in gastrointestinal disease

C Chen, X Gong, X Yang, X Shang… - Oncology …, 2019 - spandidos-publications.com
Estrogen exhibits various functions through binding to its specific receptors, estrogen receptor
α, estrogen receptor … ERβ is encoded by estrogen receptor 2 or estrogen receptor 2, which …

[HTML][HTML] Estradiol and progesterone regulate proliferation and apoptosis in colon cancer

CV Sasso, FE Santiano, FCV Arboccó… - Endocrine …, 2019 - ec.bioscientifica.com
… In addition, we observed a higher expression of estrogen receptor beta in these tumors. …
estrogen receptor beta in these tumors. We conclude that the action of both hormones, estradiol

[HTML][HTML] Prognostic value of estrogen receptor-α and progesterone receptor in curatively resected colorectal cancer: a retrospective analysis with independent …

SB Ye, YK Cheng, L Zhang, XP Wang, L Wang, P Lan - BMC cancer, 2019 - Springer
… The aim of our study was to investigate the potential impact of estrogen receptor-α (ER-α)
and progesterone receptor (PR) on the prognosis of colorectal cancer (CRC) patients who …

[HTML][HTML] Estrogen receptor beta (ERβ) mediated-CyclinD1 degradation via autophagy plays an anti-proliferation role in colon cells

Y Wei, C Huang, H Wu, J Huang - International journal of biological …, 2019 - ncbi.nlm.nih.gov
estrogens, form the basis for this protective effect in women. The functions of estrogen are
regulated by estrogen receptors … , the protective effect of estrogen may be regulated by ERβ 3 . …

Genome‐wide estrogen receptor β chromatin binding in human colon cancer cells reveals its tumor suppressor activity

R Indukuri, MH Jafferali, D Song… - … journal of cancer, 2021 - Wiley Online Library
… Studies demonstrate that estrogen activating estrogen receptor beta (ERβ) protects against
CRC. ERβ is a nuclear receptor that regulates gene expression through interactions with the …

[HTML][HTML] Estrogen-related receptor alpha directly binds to p53 and cooperatively controls colon cancer growth through the regulation of mitochondrial biogenesis and …

H De Vitto, J Ryu, A Calderon-Aparicio, J Monts… - Cancer & …, 2020 - Springer
… The estrogen-related receptor family (ERRα, ERRβ, and ERRγ) was first described as an …
receptor family and was originally identified based on its homology to estrogen receptor alpha (…