Wnt–β-catenin signalling in liver development, health and disease
MJ Perugorria, P Olaizola, I Labiano… - Nature reviews …, 2019 - nature.com
… increased β-catenin levels in rat HSCs were associated with collagen production and
proliferation 138 . In addition, expression levels of components of the Wnt–β-catenin pathway were …
proliferation 138 . In addition, expression levels of components of the Wnt–β-catenin pathway were …
WNT/β-catenin pathway activation correlates with immune exclusion across human cancers
… performed within each tumor type between β-catenin protein level and T-cell-inflamed gene
expression from normalized RNA-seq data, followed by FDR-correction for multiple testing. …
expression from normalized RNA-seq data, followed by FDR-correction for multiple testing. …
Wnt/β-catenin signaling as a driver of hepatocellular carcinoma progression: an emphasis on molecular pathways
M Deldar Abad Paskeh, S Mirzaei… - Journal of …, 2021 - Taylor & Francis
… The nuclear translocation of β-catenin enhances expression level of genes such as c-Myc
and MMPs in increasing cancer progression. The mutation of CTNNB1 gene encoding β-…
and MMPs in increasing cancer progression. The mutation of CTNNB1 gene encoding β-…
[HTML][HTML] Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
J Liu, Q Xiao, J Xiao, C Niu, Y Li, X Zhang… - Signal transduction and …, 2022 - nature.com
… ser9 and β-catenin, preventing myocardial … β-catenin to downregulate its expression.
MiR-181a-5p inhibits the 3′-UTR activity of β-catenin and TCF4, thus reducing the expression of …
MiR-181a-5p inhibits the 3′-UTR activity of β-catenin and TCF4, thus reducing the expression of …
[HTML][HTML] Beta-catenin signaling regulates barrier-specific gene expression in circumventricular organ and ocular vasculatures
… expressing a stabilized derivative of beta-catenin specifically in ECs – and thereby
artificially activating beta-catenin … In these experiments, exon 3 of the beta-catenin gene (Ctnnb1), …
artificially activating beta-catenin … In these experiments, exon 3 of the beta-catenin gene (Ctnnb1), …
[HTML][HTML] β-catenin activation down-regulates cell-cell junction-related genes and induces epithelial-to-mesenchymal transition in colorectal cancers
WK Kim, Y Kwon, M Jang, M Park, J Kim, S Cho… - Scientific reports, 2019 - nature.com
… To identify EMT transcription factors directly affected by β-catenin, we ablated β-catenin
expression in HCT116-P and HCT116-MT cells using lentiviral-encoded short hairpin RNA (…
expression in HCT116-P and HCT116-MT cells using lentiviral-encoded short hairpin RNA (…
γ-catenin overexpression in AML patients may promote tumor cell survival via activation of the Wnt/β-catenin axis
J Qian, X Huang, Y Zhang, X Ye… - OncoTargets and therapy, 2020 - Taylor & Francis
… Our results suggested that the γ-catenin mRNA expression level is … γ-catenin expression
levels had significantly shorter OS times than did patients with low γ-catenin expression levels. …
levels had significantly shorter OS times than did patients with low γ-catenin expression levels. …
[HTML][HTML] Promotion of growth factor signaling as a critical function of β-catenin during HCC progression
… To determine whether Wnt signaling is active in the context of membrane β-catenin
localization, we first assessed the expression of key Wnt target genes in primary tumors. GS is …
localization, we first assessed the expression of key Wnt target genes in primary tumors. GS is …
[HTML][HTML] Wnt/β-catenin signalling in ovarian cancer: Insights into its hyperactivation and function in tumorigenesis
VHL Nguyen, R Hough, S Bernaudo, C Peng - Journal of ovarian research, 2019 - Springer
… Ectopic expression of CCNY increased nuclear β-catenin levels and its transcriptional
activity, leading to the upregulation of downstream target genes. A previous study indicated that …
activity, leading to the upregulation of downstream target genes. A previous study indicated that …
[HTML][HTML] Wnt/beta-catenin signaling confers ferroptosis resistance by targeting GPX4 in gastric cancer
Y Wang, L Zheng, W Shang, Z Yang, T Li… - Cell Death & …, 2022 - nature.com
… that GPX4 expression was reduced by beta-catenin knockdown (… Wnt/beta-catenin signaling
pathway attenuates the levels of cellular lipid peroxidation by upregulating the expression of …
pathway attenuates the levels of cellular lipid peroxidation by upregulating the expression of …
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