Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues

M Parola, M Pinzani - Molecular aspects of medicine, 2019 - Elsevier
… injury, persistent activation of inflammatory response as well as … tissue process responsible
for driving the excess accumulation of extracellular matrix (ECM) components (ie, liver fibrosis

Implications of inflammation and fibrosis in atrial fibrillation pathophysiology

M Harada, S Nattel - Cardiac Electrophysiology Clinics, 2021 - cardiacep.theclinics.com
… Therefore, inflammation can underlie atrial fibrosis; the … In addition, the inflammasome,
an intracellular inflammatory … about inflammation and fibrosis in the pathophysiology of AF, …

Challenges in the pathophysiology, diagnosis, and management of intestinal fibrosis in inflammatory bowel disease

G D'Haens, F Rieder, BG Feagan, PDR Higgins… - …, 2022 - gastrojournal.org
fibrosis, and clinical trial end points. Basic and clinical scientists discussed the pathophysiology
of intestinal fibrosis, … advances in the understanding of fibrotic processes in other organs, …

Liver fibrosis: Pathophysiology and clinical implications

J Berumen, J Baglieri, T Kisseleva… - WIREs mechanisms of …, 2021 - Wiley Online Library
… describe the different cell types and pathways involved in the pathophysiology of liver fibrosis.
… -derived fibrogenic factors cannot lead to liver fibrosis in absence of chronic inflammation. …

Renal inflammation and fibrosis: a double-edged sword

LM Black, JM Lever, A Agarwal - Journal of Histochemistry …, 2019 - journals.sagepub.com
… Normal tissue repair processes … -inflammatory and pro-fibrotic cell types causes excess
extracellular matrix deposition. This review focuses on the physiological and pathophysiological

[PDF][PDF] Cytokine networks in the pathophysiology of inflammatory bowel disease

M Friedrich, M Pohin, F Powrie - Immunity, 2019 - cell.com
… , fibrosis. This could be explained by a model … inflammation initiates tissue fibrosis but,
at later stages, excessive repair in the tissue occurs independently of classic pro-inflammatory

Cystic fibrosis: pathophysiology of lung disease

C Bergeron, AM Cantin - Seminars in respiratory and critical …, 2019 - thieme-connect.com
… Following the discovery of the cystic fibrosis transmembrane … Numerous hypotheses
explaining the excessive inflammatory … knowledge of CF pathophysiology, including significant …

Pathophysiology of systemic sclerosis: current understanding and new insights

M Cutolo, S Soldano, V Smith - Expert review of clinical …, 2019 - Taylor & Francis
… and inflammation, and diffuse fibrosis ( Figure 1 ) [Citation3,Citation4]. In conclusion, the
different pathophysiological steps are finally associated with a progressive fibrotic involvement …

[HTML][HTML] The dynamic interplay between cardiac inflammation and fibrosis

TP Thomas, LA Grisanti - Frontiers in physiology, 2020 - frontiersin.org
Inflammation also plays a critical role in the … inflammatory and fibrotic response. This review
discusses the cellular and molecular mechanisms contributing to inflammation and fibrosis

[HTML][HTML] Transforming growth factor–β in tissue fibrosis

NG Frangogiannis - Journal of Experimental Medicine, 2020 - rupress.org
Tissue fibrosis, the excessive or dysregulated deposition of extracellular matrix (ECM) …
common pathophysiologic companion of a wide range of diseases. Although significant fibrosis is …