… to cardiovascular pathophysiology and fibrosis progression, … inflammation, the above-mentioned
pro-fibrotic factors and myofibroblasts remain activated, contributing to adverse tissue …

… The present review will therefore first focus on pathophysiological mechanisms linking
systemic inflammation to myocardial stiffness. It will subsequently address inflammatory/fibrotic …

… Idiopathic pulmonary fibrosis (IPF) is a progressive, lethal fibrotic … Although the exact
pathophysiological mechanisms underlying … The inflammatory and fibrotic mediators and immune …

… in metabolic and inflammatory insults. On the other hand, storage of fat in adipose tissue or
liver … liver histology, underlining the complex pathophysiology of these conditions. Specific …

… stages of the fibrotic process including inflammation, vascular … tissue injury results in
excessive and uncontrolled ECM deposition (Citation1). Pathophysiological stages of fibrosis …

… in pathophysiological processes. Myofibroblasts mediate wound contractions, but their
persistent presence in tissues is central to driving fibrosis, … into inflammation-induced fibrosis has …

… and development of fibrosis in two inflammatory ILDs, ie … IPF, a typical progressive fibrosis
with limited inflammation. We then … many challenges since the pathophysiology and even the …

… basis of the pathophysiological mechanisms of EMT, their regulation, and the roles played by
EMT in fibrotic … and inflammatory cells in the fibrotic tissue. In fact, in various models of liver …

… These ECM proteins are produced in increased amounts in lung fibrosis (88) and endothelial
inflammation (89), which are features of the ANG II-mediated COVID-19 pathobiology (…

… The histopathological hallmarks include subpleural fibrosis, … The recent introduction of two
anti-fibrotic drugs, pirfenidone … that the exact pathophysiological mechanisms involved in IPF …