Agents for the prevention and treatment of age-related macular degeneration and macular edema: a literature and patent review

CT Supuran - Expert Opinion on Therapeutic Patents, 2019 - Taylor & Francis
… of fluid from the blood vessels with the consequent edema formation [Citation15,Citation16].
Similar to macular degeneration, … The compound is used as a photosensitizer for PDT, as by …

Metabolomics in age-related macular degeneration: a systematic review

XW Hou, Y Wang, CW Pan - Investigative ophthalmology & …, 2020 - iovs.arvojournals.org
Purpose: Age-related macular degeneration (AMD) is one of the leading causes of blindness
among the elderly, and the exact pathogenesis of the AMD remains unclear. The purpose …

Recent advances in age-related macular degeneration therapies

M Fabre, L Mateo, D Lamaa, S Baillif, G Pagès… - Molecules, 2022 - mdpi.com
… of fluids in the eye’s anterior fragment, leading to an increased intraocular pressure in its
posterior segment and to a degeneration … able to decrease the intraocular fluid accumulation. …

Therapeutic approaches for age-related macular degeneration

RM Galindo-Camacho, C Blanco-Llamero… - International journal of …, 2022 - mdpi.com
… In recent years, several synthetic and natural active compounds have been proposed as …
Neovascular AMD incorporates some typical lesions, such as the presence of fluid or retinal …

Metabolomic profiling of the aqueous humor in patients with wet age-related macular degeneration using UHPLC–MS/MS

G Han, P Wei, M He, H Teng, Y Chu - Journal of proteome …, 2020 - ACS Publications
degenerative disease, is becoming a leading cause of … vision loss in patients with macular
degeneration. (3) The … and unknown metabolites in complex biological fluids, tissues, and cells…

Urinary mass spectrometry profiles in age-related macular degeneration

I Lains, KM Mendez, JQ Gil, JB Miller, RS Kelly… - Journal of Clinical …, 2022 - mdpi.com
We and others have shown that patients with different severity stages of age-related macular
degeneration (AMD) have distinct plasma metabolomic profiles compared to controls. Urine …

Risk factors for progression of age‐related macular degeneration

TJ Heesterbeek, L Lorés‐Motta… - Ophthalmic and …, 2020 - Wiley Online Library
… Age‐related macular degeneration (AMD) is a degenerative disease of the macula, often
leading to progressive vision loss. The rate of disease progression can vary among individuals …

Urine nuclear magnetic resonance (NMR) metabolomics in age-related macular degeneration

I Lains, D Duarte, AS Barros, AS Martins… - Journal of proteome …, 2019 - ACS Publications
… Age-related macular degeneration (AMD) is an aging disease of the eye, which is currently
the leading cause of adult blindness in developed countries and ranks third worldwide. In …

Medication trends for age-related macular degeneration

YK Cho, DH Park, IC Jeon - International journal of molecular sciences, 2021 - mdpi.com
compounds and autoxidized by carbohydrates, lipids, or amino acids. Carbonyl compounds
… Then, leaked fluid from them leads to blindness by increasing the intraocular pressure via …

Recent advances in proteomics-based approaches to studying age-related macular degeneration: a systematic review

L García-Quintanilla, L Rodríguez-Martínez… - International Journal of …, 2022 - mdpi.com
… Although tear fluid offers numerous advantages, other fluids … of systemic and ocular fluids to
identify compounds, including … structures to the macula and finishing with the systemic fluids. …