… estimation is prone to subjective assessment, as patients as … range of bleeding frequencies
among patients with similar … an efficacy measure in patients with hemophilia with and without …

… cohort of patients who enrolled in the study may have been more likely to be adherent to
their therapy than the general hemophilia population. For the CHPS, we excluded patients and …

… We estimated … hemophilia patients and detected arthropathy in 36.5%. Despite the different
methods to detect arthropathy, the rate was equal to the 36.6% of mild hemophilia patients …

… Sample size estimation was not performed due to the design of the study; therefore, all of …
in both the hemophilia A and hemophilia B patients. Table 3 shows the frequency of switches …

… to assess efficacy in hemophilia is bleeding frequency. This is … and bleeding patterns in
patients with severe hemophilia A, the … to estimate a bleeding hazard corresponding to untreated …

… frequency … estimates of half-life or Vd were taken from the respective pharmaceutical
companies’ drug inserts. We used patients’ infusion logs to build a simulation model to estimate …

… collected from hemophilia-specific patient diaries used for home … patterns of hemophilia
treatment, bleeding frequency, and … per patient, the robust sandwich covariance estimate was …

… hemophilia A (PwcHA) to the general non-hemophilia A (HA) population. Patients & … then
randomly selected from the MarketScan database and frequency-matched to the HA cohorts by …

… as a measure of bleeding frequency for spontaneous bleeds, … to estimate FVIII levels in
patients with severe hemophilia A … In conclusion, in patients of all ages with severe hemophilia …

… for hemophilia patients using sparse observations as provided in routine clinical care by
hemophilia … patients [8], individual PK parameter estimates must be obtained. Such an individual …