… frontotemporal dementia (FTD). Homozygous GRN mutations cause neuronal ceroid
lipofuscinosis-11 (CLN11), a lysosome storage disease… To gain insight into the mechanisms of …

… pleiotropic mechanisms have been hypothesized at the genetic and environmental levels,
possibly explaining individual differences due to the involvement of distinct disease pathways […

… Approximately a third of frontotemporal dementia (FTD) is genetic with mutations in three …
Impaired synaptic health is a common mechanism in all three genetic variants, so developing …

… of improving our understanding of neuroinflammatory mechanisms in neurodegenerative
disorders as well as allowing monitoring disease progression and treatment. Riluzole received …

… Among the 102 screened patients, we found two disease causing mutations in PSEN1 and
… of disease mutations can contribute to an increased understanding of disease mechanisms. …

… Mitochondrial dynamics in astrocytes are far less studied compared with neurons but
could play an important role in the FTD3 disease mechanism. We examined mitochondrial …

… is frontotemporal dementia (FTD), a neurodegenerative brain disorder with a diverse clinical
presentation and multiple possible molecular pathways of disease. … disease mechanisms …

… Frontotemporal dementia (FTD), particularly the … frontotemporal dementia: Recent
advances in diagnosis and understanding of the disorder” and also potential markers of disease …

… pathway underlying neurodegenerative dementias. The identification of shared disease
mechanisms is of pivotal importance to develop treatments to delay disease progression. To this …

… many years as two distinct pathologies with different pathological mechanisms. However,
in recent years many studies have revealed that these diseases belong to a continuum, the so-…