Antitumor Effect of Simvastatin in Combination With DNA Methyltransferase Inhibitor on Gastric Cancer via GSDME-Mediated Pyroptosis

Y Xia, Y Jin, D Cui, X Wu, C Song, W Jin… - Frontiers in …, 2022 - frontiersin.org
… due to promoter hypermethylation is associated with gastric cancer (GC), which is
confirmed … (DOX)- inducible Tet-on system or DNA methyltransferase inhibitor 5-Aza-2′-deoxycytidine …

Regulatory function of DNA methylation mediated lncRNAs in gastric cancer

N Li, A Zeng, Q Wang, M Chen, S Zhu, L Song - Cancer Cell International, 2022 - Springer
DNA methylation of other cancer-related genes. In this review, we summarized the DNA
methylation-associated lncRNAs in gastric cancer … , which are DNA methyltransferase 1 (DNMT1)…

Design, synthesis and investigation of procaine based new Pd complexes as DNA methyltransferase inhibitor on gastric cancer cells

S Paşa, O Erdogan, O Cevik - Inorganic Chemistry Communications, 2021 - Elsevier
… MKN-45 human gastric cancer cell lines were used in this study. Cells were cultured in
RPMI-1640 medium supplemented with 10% fetal bovine serum FBS, 100 U/mL penicillin and …

[HTML][HTML] Therapeutic approach of Cancer stem cells (CSCs) in gastric adenocarcinoma; DNA methyltransferases enzymes in cancer targeted therapy

SE Norollahi, F Mansour-Ghanaei, F Joukar… - Biomedicine & …, 2019 - Elsevier
… GC and DNA methylation Gastric cancer (GC) or gastric adenocarcinoma is referred to as
a series of uncontrolled cell proliferation processes that causes because of the lack …

DNA methylation: an important biomarker and therapeutic target for gastric cancer

Y Zeng, H Rong, J Xu, R Cao, S Li, Y Gao… - Frontiers in …, 2022 - frontiersin.org
DNA methylation related to the cause, diagnosis, treatment, and prognosis of gastric cancer
and aims to find cancer … induce DNA methyltransferase 1 (DNMT1) and cause aberrant DNA

[HTML][HTML] Prostaglandin E2 induces DNA hypermethylation in gastric cancer in vitro and in vivo

CC Wong, W Kang, J Xu, Y Qian, STY Luk, H Chen… - Theranostics, 2019 - ncbi.nlm.nih.gov
DNA Methyltransferase (MGMT) in gastric cancer cells, leading to down-regulation of MGMT
mRNA expression. (e) PGE 2 induced promoter methylation of cannabinoid receptor type 1 (…

Histone methyltransferases useful in gastric cancer research

DA Reyes, VMS Sarría, M Salazar-Viedma… - Cancer …, 2021 - journals.sagepub.com
Gastric cancer (GC) is one of the most frequent tumors in the world. Stomach adenocarcinoma
is a heterogeneous tumor, turning the prognosis prediction and patients’ clinical …

Helicobacter pylori-induced DNA Methylation as an Epigenetic Modulator of Gastric Cancer: Recent Outcomes and Future Direction

JS Muhammad, MA Eladl, G Khoder - Pathogens, 2019 - mdpi.com
… pylori-induced DNA methylation linked to gastric cancer … ,” “DNA methylation,” in combination
with “gastric inflammation”, … The total DNA methyltransferase activity was also found to …

RNA methyltransferase NSUN2 promotes gastric cancer cell proliferation by repressing p57Kip2 by an m5C-dependent manner

L Mei, C Shen, R Miao, JZ Wang, MD Cao… - Cell death & …, 2020 - nature.com
… Indeed, Wang and colleagues 22 found that NSUN2 was associated with metastatic
progression by affecting DNA hypomethylation in human breast cancer. Gao et al. also found …

Epigenetic changes in gastric cancer induction by Helicobacter pylori

B Yousefi, M Mohammadlou… - Journal of cellular …, 2019 - Wiley Online Library
… , and NO can increase the activity of DNA methyltransferase. … the level of DNA methylation
in people with gastric cancer is … association of DNA methylation with the risk of gastric cancer. …