[HTML][HTML] Efficacy and safety of afatinib for EGFR-mutant non-small cell lung cancer, compared with gefitinib or erlotinib

Y Kim, SH Lee, JS Ahn, MJ Ahn, K Park… - Cancer Research and …, 2019 - ncbi.nlm.nih.gov
… evaluate the pattern of clinical use of three EGFR TKIs (afatinib, gefitinib, and erlotinib). We
found that gefitinib was more commonly used than erlotinib or afatinib in Korea, especially for …

Clinical outcomes of gefitinib and erlotinib in patients with NSCLC harboring uncommon EGFR mutations: A pooled analysis of 438 patients

C Wang, K Zhao, S Hu, W Dong, Y Gong, M Li, C Xie - Lung Cancer, 2022 - Elsevier
… [23], [24], [25], [26], [27], [28], [29], [30] In this study, we explored the outcomes of some
relatively frequent single uncommon EGFR mutations, and differences in efficacy and prognosis …

[HTML][HTML] A comparative study on erlotinib & gefitinib therapy in non-small cell lung carcinoma patients

P Thomas, B Vincent, C George… - Indian Journal of …, 2019 - journals.lww.com
… The adverse reactions most commonly observed during EGFRI (erlotinib and gefitinib) … be
EGFR mutated, 22.5 per cent were non-mutated and others were not tested for EGFR mutation

[HTML][HTML] Pembrolizumab in combination with erlotinib or gefitinib as first-line therapy for advanced NSCLC with sensitizing EGFR mutation

JCH Yang, SM Gadgeel, LVD Sequist, CL Wu… - Journal of Thoracic …, 2019 - Elsevier
… /IV EGFR-mutant NSCLC were treated with pembrolizumab 2 mg/kg intravenously every 3
weeks plus oral erlotinib 150 mg daily in cohort E or oral gefitinib … The most frequent treatment-…

[HTML][HTML] Comparison of effectiveness of Gefitinib, Erlotinib, and Afatinib in advanced non-small cell lung cancer patients with EGFR mutation positive in Indonesian …

N Sutandyo, A Hanafi, M Jayusman - Chinese journal of lung …, 2019 - ncbi.nlm.nih.gov
… The most common mutations were the deletion in exon 19 and … provides evidence that
gefitinib, erlotinib, and afatinib have similar effectiveness in advance stage EGFR mutation lung …

… factor receptor (EGFR) T790M mutation among first‐line gefitinib, erlotinib and afatinib‐treated non‐small cell lung cancer patients with activating EGFR mutations

YT Lin, JS Chen, WY Liao, CC Ho… - … Journal of Cancer, 2019 - Wiley Online Library
… Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) commonly are …
including impacts on secondary EGFR T790M mutation, the most frequent EGFR-TKI resistance …

[HTML][HTML] Tyrosine kinase inhibitors for the treatment of EGFR mutation-positive non–small-cell lung cancer: a clash of the generations

R Shah, JF Lester - Clinical lung cancer, 2020 - Elsevier
… Both gefitinib and erlotinib have been … with gefitinib in 319 treatment-naive patients (160
randomized to afatinib and 159 to gefitinib) with NSCLC harboring common EGFR mutations (…

[HTML][HTML] … different central nervous system efficacy among gefitinib, erlotinib and afatinib in patients with epidermal growth factor receptor mutation-positive non-small …

HA Jung, SY Woo, SH Lee, JS Ahn… - Translational Lung …, 2020 - ncbi.nlm.nih.gov
… with gefitinib or erlotinib after adjusting for both EGFR mutation … among the three most
commonly available TKIs. Therefore, … most commonly available first- or second-generation EGFR

[HTML][HTML] Recent advances on the role of EGFR tyrosine kinase inhibitors in the management of NSCLC with uncommon, non exon 20 insertions, EGFR mutations

A Passaro, T Mok, S Peters, S Popat, MJ Ahn… - Journal of Thoracic …, 2021 - Elsevier
… largely concentrated on common EGFR mutations, reflecting … analysis of compound EGFR
mutations (two uncommon mutations) … to different EGFR TKIs (erlotinib, gefitinib, afatinib, and …

Repeat biopsy procedures and T790M rates after afatinib, gefitinib, or erlotinib therapy in patients with lung cancer

K Lee, Y Kim, HA Jung, SH Lee, JS Ahn, MJ Ahn… - Lung cancer, 2019 - Elsevier
… We performed EGFR mutation tests by using the peptide nucleic acid … EGFR T790 M mutation
is the most common resistance mechanism to first-generation EGFR-TKIs (gefitinib, erlotinib