Molecular mechanisms and evolutionary consequences of spore killers in ascomycetes

S Zanders, H Johannesson - Microbiology and Molecular Biology …, 2021 - Am Soc Microbiol
… the genes of the Spok gene family underlie the Psk spore killers (49), and the relationship
between the Spok gene family … two genes of the Spok gene family, Spok1 and Spok2, as novel …

The spore killers, fungal meiotic driver elements

AA Vogan, I Martinossi-Allibert, SL Ament-Velásquez… - Mycologia, 2022 - Taylor & Francis
… Although we currently only have two examples of spore killing gene family expansion, they
both suggest that the prevailing forces promote diversification into independent drivers, rather …

[HTML][HTML] Proliferation and dissemination of killer meiotic drive loci

EC Lai, AA Vogan - Current Opinion in Genetics & Development, 2023 - Elsevier
… represent true spore killer gene families, or recent co-option of domestic gene families requires
… These observations lead us to hypothesize that gene family expansion of killer meiotic …

Killer Meiotic Drive and Dynamic Evolution of the wtf Gene Family

MT Eickbush, JM Young… - Molecular Biology and …, 2019 - academic.oup.com
… of identified meiotic drive genes. Here, we analyze the evolution of the wtf gene family of
Schizosaccharomyces pombe that contains both killer meiotic drive genes and suppressors of …

On the mechanistic basis of killer meiotic drive in fungi

SJ Saupe, H Johannesson - Annual Review of Microbiology, 2022 - annualreviews.org
Spore killers are specific genetic elements in fungi that kill … The gene family was poorly
characterized, but several … of the wtf gene family act as autonomous spore-killing elements, …

A natural fungal gene drive enacts killing via DNA disruption

AS Urquhart, DM Gardiner - Mbio, 2023 - Am Soc Microbiol
spore killer protein Spok1, which has homologues throughout the fungal tree of life, acts via
DNA disruption. Spok1 is only the second spore killer … will be conserved in this gene family. …

[HTML][HTML] A family of killers

M De Carvalho, SE Zanders - Elife, 2019 - elifesciences.org
… two new Spok genes (Spok3 and Spok4) that are both spore killers. … gene family underlies
the Psks. The combination of Spok genes at different chromosomal locations defines the spore

Combinations of Spok genes create multiple meiotic drivers in Podospora

AA Vogan, SL Ament-Velásquez, A Granger-Farbos… - Elife, 2019 - elifesciences.org
gene family underlies the Psks. The combination of Spok genes at different chromosomal
locations defines the spore … of the genes that are responsible for the Psk spore-killer types …

Making a murderer: the evolutionary framing of hybrid gamete-killers

AL Sweigart, Y Brandvain, L Fishman - Trends in Genetics, 2019 - cell.com
… not expressed because the species lacks a functional killer gene. (B) An ancestral species
… ]), but the evolutionary origins of single-locus gamete/spore-killing have not yet been …

An introgressed gene causes meiotic drive in Neurospora sitophila

J Svedberg, AA Vogan, NA Rhoades… - Proceedings of the …, 2021 - National Acad Sciences
… Spk-1 is a class of spore killer genes and we demonstrate that … gene families are caused
by single genes which can cause drive on their own (9, 11, 13, 26). All of these gene families