Epidermal growth factor receptor inhibitors as potential anticancer agents: An update of recent progress

B Sharma, VJ Singh, PA Chawla - Bioorganic Chemistry, 2021 - Elsevier
… Epidermal growth factor receptor (EGFR) is a vital intermediate in cell signaling pathway …
Here, we have discussed anti-cancer activity and growth factor receptor inhibitory activity …

Dermatologic adverse events associated with selective fibroblast growth factor receptor inhibitors: overview, prevention, and management guidelines

ME Lacouture, V Sibaud, MJ Anadkat… - The …, 2021 - academic.oup.com
… Schematic representation of dermatologic adverse events associated with fibroblast growth
factor receptor inhibition. Suggested dose modifications for dermatologic adverse events: …

Fibroblast growth factor receptors (FGFRs): structures and small molecule inhibitors

S Dai, Z Zhou, Z Chen, G Xu, Y Chen - Cells, 2019 - mdpi.com
Fibroblast growth factor receptors (FGFRs) are a family of receptor tyrosine kinases
expressed on the cell membrane that play crucial roles in both developmental and adult cells. …

Multicenter phase I study of erdafitinib (JNJ-42756493), oral pan-fibroblast growth factor receptor inhibitor, in patients with advanced or refractory solid tumors

R Bahleda, A Italiano, C Hierro, A Mita… - Clinical Cancer …, 2019 - AACR
… , a fibroblast growth factor receptor 1–3 kinase inhibitor, in … genetic alterations in fibroblast
growth factor receptors: results of a … , an inhibitor of fibroblast growth factor receptor (FGFR), in …

Fibroblast growth factor receptors as treatment targets in clinical oncology

M Katoh - Nature reviews Clinical oncology, 2019 - nature.com
… , and the benefits of FGFR inhibitors have been demonstrated in … the clinical experience
with FGFR inhibitors to date, and … FGFR inhibitors in combination regimens with other agents. …

Computational modeling of novel quinazoline derivatives as potent epidermal growth factor receptor inhibitors

MT Ibrahim, A Uzairu, S Uba, GA Shallangwa - Heliyon, 2020 - cell.com
inhibitors. The second and third generation EGFR inhibitors are referred to as irreversible
inhibitors (… of quinazoline-based kinase inhibitors for mutant epidermal growth factor receptors. …

A review on progression of epidermal growth factor receptor (EGFR) inhibitors as an efficient approach in cancer targeted therapy

A Ayati, S Moghimi, S Salarinejad, M Safavi… - Bioorganic …, 2020 - Elsevier
The identification of molecular agents inhibiting specific functions in cancer cells progression
is considered as one of the most successful plans in cancer treatment. The epidermal …

[PDF][PDF] Review on epidermal growth factor receptor (EGFR) structure, signaling pathways, interactions, and recent updates of EGFR inhibitors

DA Sabbah, R Hajjo, K Sweidan - Current topics in medicinal …, 2020 - researchgate.net
growth factor receptor (EGFR) belongs to the ERBB family of tyrosine kinase receptors. EGFR
… interaction, and the progress in the development of EGFR inhibitors have been explored. …

[HTML][HTML] Growth factor receptor signaling inhibition prevents SARS-CoV-2 replication

K Klann, D Bojkova, G Tascher, S Ciesek, C Münch… - Molecular cell, 2020 - cell.com
SARS-CoV-2 infections are rapidly spreading around the globe. The rapid development of
therapies is of major importance. However, our lack of understanding of the molecular …

[HTML][HTML] Vascular endothelial growth factor receptor (VEGFR-2)/KDR inhibitors: medicinal chemistry perspective

SJ Modi, VM Kulkarni - Medicine in Drug Discovery, 2019 - Elsevier
growth factors such as PLGF, EGF, cytokines, etc. [58]. Upregulation and activation of growth
factor receptors … This activated receptor leads to endothelial cell sprouting, increase in the …