… of infection, to help combat existing and emerging viruses. This article reviews the current
knowledge about the early events involved in hepatitis B virus (HBV) uptake into cells. …

… viral replication over the long term. A recent analysis showed a cccDNA half-life of about 40
days in NTCP-overexpressing HepG2 cells (… to epigenetic control, the recruitment of cellular …

… for immune control and long-term suppression of HBV replication. … replication-competent
transgenic mice demonstrated that the inhibition of viral replication by effector CD8 + T cells …

… NRTIs target the reverse transcriptase activity of viral polymerase to limit virus replication, …
This study identified the molecular mechanism of how T-cells not only control HBV through …

… Despite long term control of virus replication, current antiviral therapies are unable to …
investigate the viral replication cycle,5 improve the sensitivity of assays for detecting viral genome,6…

… We generated three stable HepG2 cell lines expressing control (shRNA) and two different
target regions of IFI6 (named shIFI6-1 and shIFI6-2). The downregulating efficiency of stable …

… are present during the hepatitis phases (hepatitis B e antigen (… produced preferentially by
integrated hepatitis B virus (HBV) … the balance between viral replication and immune control, …

… entry [20]; (3) HBV core protein (HBc), which comprises the viral capsid (essential for viral
replication and genome packaging) and several core-related proteins, including the secreted …

… of testing a large variety of virus mutants, the stable transfection system allows high efficiency
of virus replication, including temporally controlled viral gene expression and replication. …

… Given the critical role of the HBV capsid protein in controlling cccDNA formation, it was … of
antivirals that efficiently suppress virus replication, chronic hepatitis B remains a major public …