… order Trypanosomatidae include human African trypanosomiasis (HAT) and Chagas disease,
caused by species of Trypanosoma brucei and Trypanosoma cruzi, respectively, as well …

… profile, as a promising compound against Trypanosoma cruzi. SAR analysis also … compounds
C2 and 1g were unable to reduce parasite load, and did not prevent mouse mortality in T…

… as biologically active compounds, we designed and synthesized a new series of aryloxy‐quinones,
which were evaluated in vitro against Trypanosoma cruzi in epimastigote form. …

… caused by the protozoan Trypanosoma cruzi. Currently, only … screening led to thousands
of compounds with anti-T. … most promising nitro-heterocyclic compounds that induce cure …

… Chagas disease, caused by Trypanosoma cruzi, is a neglected tropical disease highly … on
the semisynthesis and total synthesis of new compounds targeting T. cruzi. From 1997 to 2018, …

… Based on reports found in the literature, in which nitrogenous heterocyclic compounds,
such as pyrazoles and pyridine, and the carbohydrazide subunit which are related to the …

… Chagas disease, a neglected tropical disease caused by the kinetoplastid parasite Trypanosoma
cruzi, affects 6–7 million people worldwide and causes ∼14 000 deaths per year. (1,2) …

… Imidazole is a privileged heterocyclic core in several bioactive compounds with unique
medicinal properties and appropriate pharmacokinetics profile [44-46]. Several research attempts …

… Nitrogen heterocyclic compounds have been extensively used as pharmacological scaffolds
in myriad conditions (14, 15). Among them, derivatives containing the pyrazolone nucleus …

… cruzi protozoan infection, represents a major … -Trypanosoma cruzi derivatives involving
nitroheterocycles, we report herein the synthesis of ten 1-substituted 2-nitropyrrole compounds …