… -free mice, DNA was observed markedly hypermethylated and this was associated with a
strong loss of ten-eleven-translocation activity, lower DNA methyltransferase activity, and lower …

… repressive histone modification and DNMT1-mediated DNA … elusive how these epigenetic
modifications crosstalk. Here, … ) domain of maintenance DNA methyltransferase DNMT1, a …

… Epigenetic modifications such as DNA and histone methylation functionally cooperate in …
of action of our dual G9a histone-methyltransferase and DNA-methyltransferase 1 (DNMT1) …

… by histone modifications, DNA methylation, histone variant … Histone modifications, established
and removed by modifier … that histone modifications participate in almost all the DNA-…

… of epigenetic modification with relevance to cancer treatment, focusing on histone
methyltransferases. … (G9a, Suv39h1, and PRMT5) recruit DNA methyltransferases (DNMTs) to …

… DNA methyltransferases (DNMTs) are a conserved family of cytosine methylases with crucial
roles in epigenetic … therapeutic targets for the epigenetic treatment of cancer. Therefore, …

… drugs have already been approved for clinical use, including the combination regimen of
DNA methyltransferase inhibitors (DNMTi) with histone deacetylase inhibitors (HDACi) in the …

… Most DNA methyltransferase enzymes can be categorized into one of two groups. The
first group comprises de novo DNA methyltransferases, which are primarily responsible for …

… histone-modifying enzymes, chromatin remodeling complexes, and transcription factors.
Consequently, histone modifications … Here we focus on histone modifications and regulation …

… Nucleosomes are also enriched at exons, and de novo DNA methyltransferase activity
requires histone binding, which would explain the enrichment of DNA methylation at exons. …