[HTML][HTML] DNA methyltransferase inhibitors combination therapy for the treatment of solid tumor: mechanism and clinical application
C Hu, X Liu, Y Zeng, J Liu, F Wu - Clinical Epigenetics, 2021 - Springer
… DNA methylation, an epigenetic modification, regulates gene … on DNA methyltransferase
inhibitors. We summarized the mechanisms underlying combination therapy using DNMT …
inhibitors. We summarized the mechanisms underlying combination therapy using DNMT …
[HTML][HTML] DNA methyltransferases in depression: An update
Z Duan, J Lu - Frontiers in psychiatry, 2020 - frontiersin.org
… are the key connectors, whose changes may cause the gene expression alteration in …
These epigenetic modifications include DNA methylation and demethylation, histone acetylation …
These epigenetic modifications include DNA methylation and demethylation, histone acetylation …
[HTML][HTML] Histone methyltransferase and drug resistance in cancers
C Yang, J Zhang, Y Ma, C Wu, W Cui… - Journal of Experimental & …, 2020 - Springer
… refered to the inheritable changes of gene expression without alteration in DNA sequence
[3… of epigenetics, epigenetic modifications is divided into DNA methylation, histone methylation …
[3… of epigenetics, epigenetic modifications is divided into DNA methylation, histone methylation …
Epigenetics in amyotrophic lateral sclerosis: a role for histone post-translational modifications in neurodegenerative disease
SA Bennett, R Tanaz, SN Cobos, MP Torrente - Translational research, 2019 - Elsevier
… focus on histone modifications. Both local and global changes in histone modification profiles
are … Remarkably, Dnmt inhibition with RG108, a DNA methyltransferase inhibitor, blocked …
are … Remarkably, Dnmt inhibition with RG108, a DNA methyltransferase inhibitor, blocked …
Epigenetic modification related to acetylation of histone and methylation of DNA as a key player in immunological disorders
MI Qadir, F Anwer - Critical Reviews™ in Eukaryotic Gene …, 2019 - dl.begellhouse.com
… Many of the DNA methyltransferases (DNMT) are the enzymes that catalyze this methylation
by epigenetic modifications. The addition of methyl groups into DNA strands changes the …
by epigenetic modifications. The addition of methyl groups into DNA strands changes the …
Targeting chromatin remodeling for cancer therapy
… of epigenetic drugs including the DNA methyltransferase 1 (… very little is known about epigenetic
modification of RNA and its … the recent developments in epigenetic modifications to RNA. …
modification of RNA and its … the recent developments in epigenetic modifications to RNA. …
[HTML][HTML] DNA methylation and histone H1 jointly repress transposable elements and aberrant intragenic transcripts
… hypomethylated through mutation of DNA methyltransferase MET1. Hypomethylation of genes
… Cytosine DNA methylation is an epigenetic modification that protects genome integrity by …
… Cytosine DNA methylation is an epigenetic modification that protects genome integrity by …
[HTML][HTML] Resolving DNA damage: epigenetic regulation of DNA repair
P Karakaidos, D Karagiannis, T Rampias - Molecules, 2020 - mdpi.com
… epigenetic changes in cancer cells can also affect DNA repair through loss of gene expression
of essential DNA … Combination of PARP and DNA methyltransferase inhibitors has also …
of essential DNA … Combination of PARP and DNA methyltransferase inhibitors has also …
Yeast epigenetics: the inheritance of histone modification states
CJ O'Kane, EM Hyland - Bioscience Reports, 2019 - portlandpress.com
… the role of histone modifications in yeast transcriptional silencing and details our current
understanding of how these marks contribute to the inheritance of epigenetic chromatin states. …
understanding of how these marks contribute to the inheritance of epigenetic chromatin states. …
[PDF][PDF] A review on epigenetics: Manifestations, modifications, methods & challenges
… the background viz., DNA methylation processes, histone modifications, chromatin remodeling
and nc-RNA silencing, resulting in epigenetic modifications and the eventual constitution …
and nc-RNA silencing, resulting in epigenetic modifications and the eventual constitution …