Epigenetic regulation of DNA repair genes and implications for tumor therapy

M Christmann, B Kaina - Mutation Research/Reviews in Mutation Research, 2019 - Elsevier
changes in the expression of transcription factors activating or repressing these genes, and/or
epigenetic factors changing histone modifications … the epigenetic regulation of DNA repair …

[HTML][HTML] Advances in epigenetic cancer therapeutics

C Hillyar, KS Rallis, J Varghese - Cureus, 2020 - ncbi.nlm.nih.gov
Epigenetic modifications, including DNA methylation and demethylation and histone
modifications, have been … Their targets include writers (DNA methyltransferases [DNMT], histone

O6-Methylguanine-DNA Methyltransferase (MGMT): Challenges and New Opportunities in Glioma Chemotherapy

W Yu, L Zhang, Q Wei, A Shao - Frontiers in oncology, 2020 - frontiersin.org
DNA methyltransferase which repairs damaged DNA thus avoiding cell death caused by
alkylating agents. The expression of MGMT gene is mainly regulated by epigenetic modification

[HTML][HTML] The roles of ZEB1 in tumorigenic progression and epigenetic modifications

Y Zhang, L Xu, A Li, X Han - Biomedicine & Pharmacotherapy, 2019 - Elsevier
… the epigenetic silencing of E-cadherin by recruiting multiple chromatin enzymes of E-cadherin
promoter, such as histone deacetylases (HDACs), DNA methyltransferase (DNMT) and …

Targeting epigenetic modifications in cancer therapy: erasing the roadmap to cancer

HP Mohammad, O Barbash, CL Creasy - Nature medicine, 2019 - nature.com
… The first-generation epigenetic modulators to be approved for clinical use included non-selective
DNA methyltransferase (DNMT) and histone deacetylase (HDAC) inhibitors for …

Cytosine-5 methylation-directed construction of a Au nanoparticle-based nanosensor for simultaneous detection of multiple DNA methyltransferases at the single …

LJ Wang, X Han, JG Qiu, BH Jiang, CY Zhang - Chemical Science, 2020 - pubs.rsc.org
DNA methylation at cytosine/guanine dinucleotide islands (CpGIs) is the most prominent
epigenetic modification in prokaryotic and eukaryotic genomes. DNA methyltransferases (…

Epigenetic modifications in head and neck cancer

J Gaździcka, K Gołąbek, JK Strzelczyk… - Biochemical …, 2020 - Springer
… Methylation is catalyzed by members of the family of DNA methyltransferases (DNMTs)
composed of DNMT1, DNMT2, DNMT3A, and DNMT3B. DNMT1 is a maintenance enzyme …

Drugs targeting epigenetic modifications and plausible therapeutic strategies against colorectal cancer

S Patnaik, Anupriya - Frontiers in Pharmacology, 2019 - frontiersin.org
epigenetic modificationshistone deacetylases (HDACs) and DNA methyltransferase
inhibitors as an emerging anticancer strategy. This review covers potential epigenetic modification

[HTML][HTML] The key role of DNA methylation and histone acetylation in epigenetics of atherosclerosis

HT Lee, S Oh, H Yoo, YW Kwon - Journal of lipid and …, 2020 - ncbi.nlm.nih.gov
… methylation occurs at symmetric CpG sites, starts with DNA methyltransferase (DNMT) 3A/3B…
herein the relationships between these pathogenic processes and epigenetic modifications. …

Silencing of the DNA methyltransferase 1 associated protein 1 (DMAP1) gene in the invasive ladybird Harmonia axyridis implies a role of the DNA methyltransferase …

J Gegner, T Gegner, H Vogel… - Insect Molecular …, 2020 - Wiley Online Library
… for DNA methylation and histone modification. We found that neither of these epigenetic
mechanisms … Strikingly, we found that silencing the gene encoding for DNA methyltransferase 1 …