Epigenetic regulation of DNA repair genes and implications for tumor therapy
M Christmann, B Kaina - Mutation Research/Reviews in Mutation Research, 2019 - Elsevier
… changes in the expression of transcription factors activating or repressing these genes, and/or
epigenetic factors changing histone modifications … the epigenetic regulation of DNA repair …
epigenetic factors changing histone modifications … the epigenetic regulation of DNA repair …
[HTML][HTML] Advances in epigenetic cancer therapeutics
… Epigenetic modifications, including DNA methylation and demethylation and histone
modifications, have been … Their targets include writers (DNA methyltransferases [DNMT], histone …
modifications, have been … Their targets include writers (DNA methyltransferases [DNMT], histone …
O6-Methylguanine-DNA Methyltransferase (MGMT): Challenges and New Opportunities in Glioma Chemotherapy
W Yu, L Zhang, Q Wei, A Shao - Frontiers in oncology, 2020 - frontiersin.org
… DNA methyltransferase which repairs damaged DNA thus avoiding cell death caused by
alkylating agents. The expression of MGMT gene is mainly regulated by epigenetic modification…
alkylating agents. The expression of MGMT gene is mainly regulated by epigenetic modification…
[HTML][HTML] The roles of ZEB1 in tumorigenic progression and epigenetic modifications
Y Zhang, L Xu, A Li, X Han - Biomedicine & Pharmacotherapy, 2019 - Elsevier
… the epigenetic silencing of E-cadherin by recruiting multiple chromatin enzymes of E-cadherin
promoter, such as histone deacetylases (HDACs), DNA methyltransferase (DNMT) and …
promoter, such as histone deacetylases (HDACs), DNA methyltransferase (DNMT) and …
Targeting epigenetic modifications in cancer therapy: erasing the roadmap to cancer
HP Mohammad, O Barbash, CL Creasy - Nature medicine, 2019 - nature.com
… The first-generation epigenetic modulators to be approved for clinical use included non-selective
DNA methyltransferase (DNMT) and histone deacetylase (HDAC) inhibitors for …
DNA methyltransferase (DNMT) and histone deacetylase (HDAC) inhibitors for …
Cytosine-5 methylation-directed construction of a Au nanoparticle-based nanosensor for simultaneous detection of multiple DNA methyltransferases at the single …
… DNA methylation at cytosine/guanine dinucleotide islands (CpGIs) is the most prominent
epigenetic modification in prokaryotic and eukaryotic genomes. DNA methyltransferases (…
epigenetic modification in prokaryotic and eukaryotic genomes. DNA methyltransferases (…
Epigenetic modifications in head and neck cancer
J Gaździcka, K Gołąbek, JK Strzelczyk… - Biochemical …, 2020 - Springer
… Methylation is catalyzed by members of the family of DNA methyltransferases (DNMTs)
composed of DNMT1, DNMT2, DNMT3A, and DNMT3B. DNMT1 is a maintenance enzyme …
composed of DNMT1, DNMT2, DNMT3A, and DNMT3B. DNMT1 is a maintenance enzyme …
Drugs targeting epigenetic modifications and plausible therapeutic strategies against colorectal cancer
S Patnaik, Anupriya - Frontiers in Pharmacology, 2019 - frontiersin.org
… epigenetic modifications … histone deacetylases (HDACs) and DNA methyltransferase
inhibitors as an emerging anticancer strategy. This review covers potential epigenetic modification …
inhibitors as an emerging anticancer strategy. This review covers potential epigenetic modification …
[HTML][HTML] The key role of DNA methylation and histone acetylation in epigenetics of atherosclerosis
HT Lee, S Oh, H Yoo, YW Kwon - Journal of lipid and …, 2020 - ncbi.nlm.nih.gov
… methylation occurs at symmetric CpG sites, starts with DNA methyltransferase (DNMT) 3A/3B…
herein the relationships between these pathogenic processes and epigenetic modifications. …
herein the relationships between these pathogenic processes and epigenetic modifications. …
Silencing of the DNA methyltransferase 1 associated protein 1 (DMAP1) gene in the invasive ladybird Harmonia axyridis implies a role of the DNA methyltransferase …
J Gegner, T Gegner, H Vogel… - Insect Molecular …, 2020 - Wiley Online Library
… for DNA methylation and histone modification. We found that neither of these epigenetic
mechanisms … Strikingly, we found that silencing the gene encoding for DNA methyltransferase 1 …
mechanisms … Strikingly, we found that silencing the gene encoding for DNA methyltransferase 1 …