… HIV-1 and the type 1 IFN signaling pathway, and examine the efficacy of type 1 IFNs in
vivo. We also explore whether limited type 1 IFN manipulation may have a therapeutic role. …

… interferon γ-inducible protein 16 (IFI16) is known as immune sensor of retroviral DNA
intermediates. We show that IFI16 restricts HIV-1 … Highly prevalent clade C HIV-1 strains are more …

… to the HIV long terminal repeat and activate HIV transcription. We demonstrate diverse effects
of interferons on HIV … of latency but also reversing HIV latency once latency is established. …

… nonstructural protein viral infectivity factor (Vif) is essential in HIV-1 replication, as it … the
production of type I IFN to promote immune evasion. HIV-1 infection induced the activation of the …

… that IFN-I may contribute to MAIT cell impairment during chronic HIV-1 infection. By … assays
of MAIT cells from HIV-infected patients, we show that sustained IFN-I stimulation induces IL-…

… The authors found that HIV-1 isolates acquired at the time of initial infection or during … type
1 interferons. These findings underpin the importance of type 1 interferons in controlling HIV-1 …

… type I interferon (IFN) inhibits the expression of HIV-1 Gag-Pol. MT4 cells were infected with
the replication-competent HIV-1 virus NL4-3 and then treated with IFN. Considering that IFN …

… Human immunodeficiency virus type 1 (HIV-1) is a unique … During the replication cycle,
HIV-1 undergoes reverse … However, HIV-1 has evolved efficient strategies to evade or …

… The studies cited in this review analyze the effects of HIV-1 at the molecular level and how
HIV-1 damages CNS cells. However, a link that defines a clear mechanism of how the virus …

… We also found that Meth enhances HIV-1 replication via IL-1 signaling. Our results … favor
HIV-1 replication. These observations offer a framework for designing targeted therapies in HIV-…