… Estrogen receptors such as ERα and ERβ activate intracellular signaling cascades followed
… In this review, we discuss the roles of estrogen receptors and their multiple molecular targets …

… Abnormal estrogen receptor signaling may increase the risk of development of a variety of
diseases including colorectal cancer (CRC). Estrogen receptor beta (ERβ) is the predominant …

… Colorectal cancer (CRC) is the third leading cause of cancer … demonstrate that estrogen
activating estrogen receptor beta (… intracellular signal transduction in both cell lines (Figure 3C). …

… machinery causes tumorigenesis, including colorectal cancer (CRC). Overexpression of …
Autophagy is a conserved evolutionary and intracellular degradation pathway in eukaryotic …

… in endocrine-related cancers: breast, prostate, and thyroid, and colorectal cancers. We also
… genomic action of estrogen starts upon ligand binding to the cytosolic receptor, followed by …

… estrogen receptors, ERβ, in particular, has been suggested to act as a tumor suppressor in
colorectal cancer … increased expression of GPER in the cytoplasm of mast cells, which are …

… have suggested an inhibitory role of estrogens against colorectal cancer (CRC), but persistent
… It is known that free ERs located in the cytoplasm dimerize upon estrogen binding, and the …

… signals to mediate intracellular responses [19]. The classical mechanism through which …
and cell proliferation in colorectal cancer [69]. The absence of ERβ in the tumor is a risk factor …

… the cytoplasmic YAP was phosphorylated, we extracted the nucleus and cytoplasmic extracts
… The role of GPER in colorectal cancer has been a controversial topic. It is suggested GPER …

… receptor and only two have been linked to intracellular signaling [20]. OB-Rb is the longest
isoform of the leptin receptor … There are three forms of oestrogen receptors: ERα, ERβ and G-…