[HTML][HTML] Alzheimer disease: an update on pathobiology and treatment strategies
JM Long, DM Holtzman - Cell, 2019 - cell.com
Alzheimer disease (AD) is a heterogeneous disease with a complex pathobiology. The presence
of extracellular β-amyloid deposition as neuritic plaques and intracellular accumulation …
of extracellular β-amyloid deposition as neuritic plaques and intracellular accumulation …
The human connectome in Alzheimer disease—relationship to biomarkers and genetics
… Alzheimer disease (AD) is a prevalent and … the disease progresses, this neurodegeneration
gradually spreads to the temporal and parietal cortices and, eventually, to most of the cortex. …
gradually spreads to the temporal and parietal cortices and, eventually, to most of the cortex. …
Alzheimer disease
DS Knopman, H Amieva, RC Petersen… - Nature reviews Disease …, 2021 - nature.com
… When mice expressing human tau and Aβ were examined, there was a tau-dependent
quieting of neural system activity in the parietal cortex with or without neuronal loss 106 , which …
quieting of neural system activity in the parietal cortex with or without neuronal loss 106 , which …
Early Alzheimer's disease pathology in human cortex involves transient cell states
… Alzheimer’s disease (AD) are primarily studied in human postmortem samples and model
organisms. Here, we generated a single-nucleus atlas from a rare cohort of cortical … -disease …
organisms. Here, we generated a single-nucleus atlas from a rare cohort of cortical … -disease …
Associations between tau, Aβ, and cortical thickness with cognition in Alzheimer disease
R Ossenkoppele, R Smith, T Ohlsson, O Strandberg… - Neurology, 2019 - AAN Enterprises
… test battery covering major cognitive functions, including global cognition (MMSE),
episodic memory (immediate and delayed word list recall tests from the Alzheimer's Disease …
episodic memory (immediate and delayed word list recall tests from the Alzheimer's Disease …
An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations
… Alzheimer disease traits In the present study, we investigated the association of human
cortical circRNA expression with AD case–control status, ADAD case–control status and two AD …
cortical circRNA expression with AD case–control status, ADAD case–control status and two AD …
Amyloid-β-independent regulators of tau pathology in Alzheimer disease
R van der Kant, LSB Goldstein… - Nature Reviews …, 2020 - nature.com
… cortex and spreads to limbic areas in patients with mild cognitive impairment (MCI) due to
Alzheimer disease (… By contrast, Aβ pathology starts in association cortices and spreads from …
Alzheimer disease (… By contrast, Aβ pathology starts in association cortices and spreads from …
Mechanical property alterations across the cerebral cortex due to Alzheimer's disease
… (A) The structural anatomical image and stiffness map for a healthy 68-year-old female
control (OA), and (B) the same information for a 71-year-old female with Alzheimer's disease. (C) …
control (OA), and (B) the same information for a 71-year-old female with Alzheimer's disease. (C) …
Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes
R Nortley, N Korte, P Izquierdo, C Hirunpattarasilp… - Science, 2019 - science.org
… Nortley et al. found that, both in humans developing Alzheimer's disease (AD) and in a …
deposition, and we calculated that in the human cortex this constriction would have the effect of …
deposition, and we calculated that in the human cortex this constriction would have the effect of …
Lifespan changes of the human brain in Alzheimer's disease
Brain imaging studies have shown that slow and progressive cerebral atrophy characterized
the development of Alzheimer’s Disease (AD). Despite a large number of studies dedicated …
the development of Alzheimer’s Disease (AD). Despite a large number of studies dedicated …
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