[HTML][HTML] Alzheimer disease: an update on pathobiology and treatment strategies

JM Long, DM Holtzman - Cell, 2019 - cell.com
Alzheimer disease (AD) is a heterogeneous disease with a complex pathobiology. The presence
of extracellular β-amyloid deposition as neuritic plaques and intracellular accumulation …

The human connectome in Alzheimer disease—relationship to biomarkers and genetics

M Yu, O Sporns, AJ Saykin - Nature Reviews Neurology, 2021 - nature.com
Alzheimer disease (AD) is a prevalent and … the disease progresses, this neurodegeneration
gradually spreads to the temporal and parietal cortices and, eventually, to most of the cortex. …

Alzheimer disease

DS Knopman, H Amieva, RC Petersen… - Nature reviews Disease …, 2021 - nature.com
… When mice expressing human tau and Aβ were examined, there was a tau-dependent
quieting of neural system activity in the parietal cortex with or without neuronal loss 106 , which …

Early Alzheimer's disease pathology in human cortex involves transient cell states

V Gazestani, T Kamath, NM Nadaf, A Dougalis… - Cell, 2023 - cell.com
Alzheimer’s disease (AD) are primarily studied in human postmortem samples and model
organisms. Here, we generated a single-nucleus atlas from a rare cohort of cortical … -disease

Associations between tau, Aβ, and cortical thickness with cognition in Alzheimer disease

R Ossenkoppele, R Smith, T Ohlsson, O Strandberg… - Neurology, 2019 - AAN Enterprises
… test battery covering major cognitive functions, including global cognition (MMSE),
episodic memory (immediate and delayed word list recall tests from the Alzheimer's Disease

An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations

U Dube, JL Del-Aguila, Z Li, JP Budde, S Jiang… - Nature …, 2019 - nature.com
Alzheimer disease traits In the present study, we investigated the association of human
cortical circRNA expression with AD case–control status, ADAD case–control status and two AD …

Amyloid-β-independent regulators of tau pathology in Alzheimer disease

R van der Kant, LSB Goldstein… - Nature Reviews …, 2020 - nature.com
cortex and spreads to limbic areas in patients with mild cognitive impairment (MCI) due to
Alzheimer disease (… By contrast, Aβ pathology starts in association cortices and spreads from …

Mechanical property alterations across the cerebral cortex due to Alzheimer's disease

LV Hiscox, CL Johnson, MDJ McGarry… - Brain …, 2020 - academic.oup.com
… (A) The structural anatomical image and stiffness map for a healthy 68-year-old female
control (OA), and (B) the same information for a 71-year-old female with Alzheimer's disease. (C) …

Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes

R Nortley, N Korte, P Izquierdo, C Hirunpattarasilp… - Science, 2019 - science.org
… Nortley et al. found that, both in humans developing Alzheimer's disease (AD) and in a …
deposition, and we calculated that in the human cortex this constriction would have the effect of …

Lifespan changes of the human brain in Alzheimer's disease

P Coupé, JV Manjón, E Lanuza, G Catheline - Scientific reports, 2019 - nature.com
Brain imaging studies have shown that slow and progressive cerebral atrophy characterized
the development of Alzheimer’s Disease (AD). Despite a large number of studies dedicated …