… To investigate the potential of CAR T cells to actively recruit endogenous members of the
immune system, we relied on a syngeneic immunocompetent mouse model. A previously …

… CD40L boosts the immune system’s ability to identify tumor-specific antigens and initiate a
targeted immune response … , CD40L plays a pivotal role in boosting the immune response to …

… The CD40/CD40L pathway plays a pivotal role in the activation and progression of cellular
and humoral adaptive immune response [4]. Several studies have implicated this pathway in …

… of immunological memory in the adaptive immune system. In essence, TNF and CD40L …
mediated activation of the innate immune system via TNFR and CD40-induced inflammation. We …

… The interaction between CD40 and CD154 (CD40 ligand) is central in immunology, …
signal early in immune system evolution, as suggested by the CD40-CD154 dependence …

… (APCs), and even by non-immunologic cells such as endothelial cells, fibroblasts, …
CD40L-CD40 axis impairs diverse biologic responses related to different cell lineages, making …

… could provide insight into modulating humoral immune responses to improve therapies for
… CD40 plays a crucial role in T-cell dependent humoral immune responses as seen by lack of …

… It acts as a co-stimulatory molecule, influencing the function of CD40-expressing cells: B …
and other cells not directly related to immune response. CD40L-CD40 binding in B cells causes …

… The CD40–CD40L pathway is central to SLE pathogenesis and … CD40 is expressed on
immune cells (including B cells, … Interactions between CD40L on T cells and CD40 on B cells in …

… In contrast, CD40L-CD40-TRAF2/3/5 signaling seems to have a more regulatory function in
the immune system and may contribute to resolution. Regarding TRAF7 (74 kDa) and its role …