… The CD40–CD40L costimulatory pathway regulates adaptive and innate immune responses
… Frexalimab is a second-generation anti-CD40L monoclonal antibody being evaluated for …

… This demonstrates that the mutant virus is still pathogenic, but the host immune response
can control the infection and prevent disease after peripheral exposure. Prior studies have …

… in groups immunized with pcDNA-CD40L-Nef and pcDNA-IFNγ-Nef indicating the importance
of strong Th1 immune response compared to Th2 immune response. As a result of the in …

… Interaction between CD40 and CD40L is an essential signaling pathway involved in
immune responses and plays a crucial role in regulating various cellular functions. Because …

… The costimulatory CD40–CD40L dyad has a critical role in driving immune responses and
… No differences in peripheral immune responses were observed (see supplementary material…

… CD40L plays a central role in co-stimulation and regulation of the immune response via
activation of cells expressing CD40. Imbalance of the CD40–CD40L co-stimulatory pathway has …

… We found in humans that IFA enhances systemic immune responses and that repeat
vaccination at one site (same site vaccination (SSV)) creates tertiary lymphoid structures (TLS) in …

… physiological and immunological context of CD40/CD40L, … the immune system and tumour
cells, agonistic anti-CD40 … , demonstrating potent antitumour immune responses in animal …

… To test the hypothesis that ligation of the CD40/CD40L axis would promote brainstem tumor
… structures and the generation of the antiglioma immune responses in our model. In addition, …

… between CD40L and CD40 can directly inhibit growth of CD40-positive … immune responses.
Citation24 However, in this early investigation, the specific molecular mechanism of CD40L …