[HTML][HTML] Constitutive immune mechanisms: mediators of host defence and immune regulation

SR Paludan, T Pradeu, SL Masters… - Nature Reviews …, 2021 - nature.com
… or potentially disruptive immune responses. In addition, vigorous immune responses are not
… RNAi is another constitutive immune mechanism that directly controls viral replication. RNAi …

[HTML][HTML] Gut microbiome and health: mechanistic insights

WM De Vos, H Tilg, M Van Hul, PD Cani - Gut, 2022 - gut.bmj.com
… and possibly immune diseases.23 Support for this and further new insight derived from …
have been found to affect the host immune response, providing an experimental system for …

[HTML][HTML] B cell depletion therapies in autoimmune disease: advances and mechanistic insights

DSW Lee, OL Rojas, JL Gommerman - Nature reviews Drug discovery, 2021 - nature.com
Immune responses to antigens occur within secondary lymphoid organs (lymph nodes,
tonsils and spleen): the spleen supports immune responses to blood-borne antigens, whereas …

New insights into the immune functions of complement

ES Reis, DC Mastellos, G Hajishengallis… - Nature Reviews …, 2019 - nature.com
mechanism during a T cell immune response 105 . It has been suggested that co-ligation
of MCP and CD35 on activated CD4 + T cells further potentiates the production of IL-10 by …

Toll‐like receptor polymorphism in host immune response to infectious diseases: A review

S Mukherjee, S Huda… - Scandinavian journal of …, 2019 - Wiley Online Library
… Population-based study dissecting the mechanistic insights of the effect of natural selection
upon human TLRs involving 158 individuals from different parts of the globe revealed that …

[HTML][HTML] Mechanistic insight into diabetic wounds: Pathogenesis, molecular targets and treatment strategies to pace wound healing

S Patel, S Srivastava, MR Singh, D Singh - Biomedicine & …, 2019 - Elsevier
… Although numerous studies are available that support delayed wound healing in diabetes
but detailed mechanistic insight including factors involved and their role still needs to be …

[HTML][HTML] Tumor microenvironment: a metabolic player that shapes the immune response

S Cassim, J Pouyssegur - International journal of molecular sciences, 2019 - mdpi.com
insights on how tumor microenvironment metabolically instructs immune responsiveness. …
Mechanistically, tryptophan depletion activates general control nonderepressible 2 (GCN2), …

[HTML][HTML] Modulation of immune responses by particle size and shape

MV Baranov, M Kumar, S Sacanna… - Frontiers in …, 2021 - frontiersin.org
… and subsequent immune responses, particularly inflammasome activation and T cell activation.
Understanding how the physical properties of particles affect immune responses can aid …

Epigenetic regulation of the innate immune response to infection

Q Zhang, X Cao - Nature Reviews Immunology, 2019 - nature.com
… viral RNAs and preventing an excessive immune response and inflammatory damage 47 .
This mechanism may be used by viruses for immune evasion, contributing to chronic infection. …

[HTML][HTML] Immune response in COVID-19: addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2

M Catanzaro, F Fagiani, M Racchi, E Corsini… - Signal transduction and …, 2020 - nature.com
… system in COVID-19, a deeper understanding of the mechanism behind the immune
dysregulation might give us clues for the clinical management of the severe cases and for …