The effects of bariatric surgery on islet function, insulin secretion, and glucose control

JD Douros, J Tong, DA D'Alessio - Endocrine reviews, 2019 - academic.oup.com
… to factors governing glucose metabolism and insulin secretion after the commonly used RYGB
… substrates, which has implications for islet regulation and insulin secretion after surgery. …

[HTML][HTML] Assessment of insulin secretion and insulin resistance in human

SY Park, JF Gautier, S Chon - Diabetes & metabolism …, 2021 - synapse.koreamed.org
… In order to evaluate acute and late insulin secretory function and maximum insulin secretory
capacity, dynamic test-based measurement is required. An appropriate method should be …

[HTML][HTML] Noncanonical regulation of cAMP-dependent insulin secretion and its implications in type 2 diabetes

S Ramanadham, J Turk, S Bhatnagar - Comprehensive Physiology, 2023 - ncbi.nlm.nih.gov
… Subsequently, a sustained second phase of insulin secretion persists for several hours with
relatively reduced insulin secretion rates. During this sustained phase, insulin granules from …

Mechanisms controlling pancreatic islet cell function in insulin secretion

JE Campbell, CB Newgard - Nature reviews Molecular cell biology, 2021 - nature.com
insulin action and a loss of the normal insulin secretion response to glucose. Glucose
stimulates insulin secretion … or amplifying phase of this secretory response, have been recently …

[HTML][HTML] Hydrogen sulfide regulates insulin secretion and insulin resistance in diabetes mellitus, a new promising target for diabetes mellitus treatment? A review

H Zhang, Y Huang, S Chen, C Tang, G Wang… - Journal of advanced …, 2021 - Elsevier
… This study aimed to summarize and discuss current data about the function of H2S in
insulin secretion and insulin resistance regulation as well as the underlying mechanisms. …

Current perspective on the role of insulin and glucagon in the pathogenesis and treatment of type 2 diabetes mellitus

A Ojha, U Ojha, R Mohammed… - Clinical …, 2019 - Taylor & Francis
… The primary stimulant for insulin secretion from the pancreatic β-cell is hyperglycemia.
Citation11 Glucose is transported into the β-cell by the protein Glucose Transporter 2 (GLUT2). …

Serotonergic regulation of insulin secretion

LR Cataldo Bascuñan, C Lyons, H Bennet… - Acta …, 2019 - Wiley Online Library
… Physiological insulin secretion occurs in a biphasic manner with a robust peak in insulin
secretion, … There may be ample pharmacological implications for future therapeutic opportunities …

The role of incretins on insulin function and glucose homeostasis

JJ Holst, LS Gasbjerg, MM Rosenkilde - Endocrinology, 2021 - academic.oup.com
… The incretin effect—the amplification of insulin secretion after oral vs intravenous
administration of glucose as a mean to improve glucose tolerance—was suspected even before …

Insulin and growth hormone balance: implications for obesity

Z Huang, L Huang, MJ Waters, C Chen - Trends in Endocrinology & …, 2020 - cell.com
insulin and GH at the cellular level, and summarize recent findings. We analyze changes in
the insulin–… we discuss the implications of the insulin–GH balance in the treatment of obesity. …

Connecting pancreatic islet lipid metabolism with insulin secretion and the development of type 2 diabetes

Y Imai, RS Cousins, S Liu, BM Phelps… - Annals of the New …, 2020 - Wiley Online Library
… To better understand the two-sided relationship between lipids and beta cells, we present
a current view of acute and chronic handling of lipids by beta cells and implications for beta …