[HTML][HTML] Resolving the paradox of hepatic insulin resistance
D Santoleri, PM Titchenell - Cellular and molecular gastroenterology and …, 2019 - Elsevier
… because overexpression of hepatic ChREBP in mice results in steatosis. Consistent with …
showed mild insulin resistance and protection from hepatic steatosis when challenged with …
showed mild insulin resistance and protection from hepatic steatosis when challenged with …
[HTML][HTML] Role of insulin resistance in MAFLD
Y Sakurai, N Kubota, T Yamauchi… - International journal of …, 2021 - mdpi.com
… Transient overexpression of ChREBP in the liver results in hepatic steatosis without
insulin resistance through induction of the lipogenic enzyme Scd1 [181]. Transient liver-specific …
insulin resistance through induction of the lipogenic enzyme Scd1 [181]. Transient liver-specific …
[HTML][HTML] The role of insulin resistance and diabetes in nonalcoholic fatty liver disease
… -hepatic organs influence NAFLD progression [12,13,14,15]. Progressive adipose tissue
dysfunction and insulin resistance … modulate the onset of hepatic steatosis and molecular events …
dysfunction and insulin resistance … modulate the onset of hepatic steatosis and molecular events …
[HTML][HTML] Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease
GI Smith, M Shankaran, M Yoshino… - The Journal of …, 2020 - Am Soc Clin Investig
… Taken together, these data underscore the importance of DNL in the pathogenesis of
hepatic steatosis and suggest that increases in daily 24-hour plasma glucose and …
hepatic steatosis and suggest that increases in daily 24-hour plasma glucose and …
[HTML][HTML] Vitamin D receptor activation in liver macrophages ameliorates hepatic inflammation, steatosis, and insulin resistance in mice
… of insulin on lipogenesis remains intact, leading to hyperglycemia, hyperinsulinemia, and
hepatic steatosis… development of steatosis, a characteristic feature of hepatic insulin resistance. …
hepatic steatosis… development of steatosis, a characteristic feature of hepatic insulin resistance. …
[HTML][HTML] Hepatic deficiency of selenoprotein S exacerbates hepatic steatosis and insulin resistance
L Qiao, L Men, S Yu, J Yao, Y Li, M Wang, Y Yu… - Cell Death & …, 2022 - nature.com
… insulin resistance (IR) and genetic susceptibility. The hallmark of NAFLD is hepatic steatosis,
… We reveal that the loss of hepatic SelS leads to obesity, hepatic steatosis, IR and disturbed …
… We reveal that the loss of hepatic SelS leads to obesity, hepatic steatosis, IR and disturbed …
Targeting a ceramide double bond improves insulin resistance and hepatic steatosis
B Chaurasia, TS Tippetts, R Mayoral Monibas, J Liu… - Science, 2019 - science.org
… insulin action and apoptosis (1, 5). To investigate the effects of manipulations targeting the 4,5
double bond in ceramides on insulin resistance and hepatic steatosis… and hepatic steatosis…
double bond in ceramides on insulin resistance and hepatic steatosis… and hepatic steatosis…
Molecular mechanisms of hepatic insulin resistance in nonalcoholic fatty liver disease and potential treatment strategies
C Zhang, B Zhou, J Sheng, Y Chen, Y Cao… - Pharmacological …, 2020 - Elsevier
… Ceramide plays an important role in IR, such as that inhibition of ceramide synthesis
alleviates hepatic steatosis and fibrosis in NAFLD rats [30], increased production and release of …
alleviates hepatic steatosis and fibrosis in NAFLD rats [30], increased production and release of …
Fructose and hepatic insulin resistance
… On the other hand, increased oxidation of FFA via upregulation of PPARα is sufficient to
reverse hepatic steatosis and insulin resistance in mice fed high-fructose diet [Citation50]. FFAs …
reverse hepatic steatosis and insulin resistance in mice fed high-fructose diet [Citation50]. FFAs …
Improvement in insulin resistance and estimated hepatic steatosis and fibrosis after endoscopic sleeve gastroplasty
K Hajifathalian, A Mehta, B Ang, D Skaf, SL Shah… - Gastrointestinal …, 2021 - Elsevier
… estimated hepatic steatosis … hepatic steatosis and fibrosis after ESG in patients with NAFLD.
Importantly, we showed an early and weight-independent improvement in insulin resistance, …
Importantly, we showed an early and weight-independent improvement in insulin resistance, …
相关搜索
- insulin resistance hepatic de novo lipogenesis
- insulin resistance hepatic inflammation
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- insulin resistance fatty liver disease
- selective insulin resistance
- insulin resistance metabolic syndrome
- insulin resistance molecular mechanisms
- insulin signaling increased hepatic steatosis
- cause of insulin resistance
- insulin resistance in hepatocytes
- insulin resistance in the liver
- implications for insulin resistance
- potential treatment strategies hepatic insulin resistance
- liver macrophages insulin resistance in mice