… because overexpression of hepatic ChREBP in mice results in steatosis. Consistent with …
showed mild insulin resistance and protection from hepatic steatosis when challenged with …

… Transient overexpression of ChREBP in the liver results in hepatic steatosis without
insulin resistance through induction of the lipogenic enzyme Scd1 [181]. Transient liver-specific …

… -hepatic organs influence NAFLD progression [12,13,14,15]. Progressive adipose tissue
dysfunction and insulin resistance … modulate the onset of hepatic steatosis and molecular events …

… Taken together, these data underscore the importance of DNL in the pathogenesis of
hepatic steatosis and suggest that increases in daily 24-hour plasma glucose and …

… of insulin on lipogenesis remains intact, leading to hyperglycemia, hyperinsulinemia, and
hepatic steatosis… development of steatosis, a characteristic feature of hepatic insulin resistance. …

… insulin resistance (IR) and genetic susceptibility. The hallmark of NAFLD is hepatic steatosis,
… We reveal that the loss of hepatic SelS leads to obesity, hepatic steatosis, IR and disturbed …

… insulin action and apoptosis (1, 5). To investigate the effects of manipulations targeting the 4,5
double bond in ceramides on insulin resistance and hepatic steatosis… and hepatic steatosis…

… Ceramide plays an important role in IR, such as that inhibition of ceramide synthesis
alleviates hepatic steatosis and fibrosis in NAFLD rats [30], increased production and release of …

… On the other hand, increased oxidation of FFA via upregulation of PPARα is sufficient to
reverse hepatic steatosis and insulin resistance in mice fed high-fructose diet [Citation50]. FFAs …

… estimated hepatic steatosis … hepatic steatosis and fibrosis after ESG in patients with NAFLD.
Importantly, we showed an early and weight-independent improvement in insulin resistance, …