… sensing mechanisms of SARS-CoV-2 and the mechanisms of SARS-CoV-2-mediated
inhibition of IFN responses. We also discuss the dysregulation of IFN responses in the context of …

… of the complex interplay between SARS-CoV-2 infection and the IFN system, highlighting
some … conserved IFN evasion strategies that are likely shared with SARS-CoV and MERS-CoV, …

… IFN-β treatment effectively blocks SARS-CoV-2 replication. In summary, our study shows
that SARS-CoV-2 perturbs host innate immune response via … the pathogenesis of SARS-CoV-2. …

… role of immune response to SARS-CoV-2 infection as well as recent publications on
characteristics and outcomes of COVID-19, and their relationship with interferons type I and type III. …

… In addition, these findings could have key implications for animal model development as
well as further research into how SARS-CoV-2 modulates the type I IFN response early during …

… We will further discuss the mechanisms that SARS-CoV-2 uses to evade IFN responses, and
the … between SARS-CoV-2 and IFN to better inform treatments that exploit IFN functions to …

… Many of these genes are known to antagonize or evade the interferon response, which may
contribute to the delayed IFN expression seen in COVID-19 patients. These proteins act both …

… response are lacking. Here, we use unbiased screening to identify SARS-CoV-2 proteins
that antagonize type I interferon (IFN-I) response. We found three proteins that antagonize …

… in IFN-I responses, 5 we next investigated whether Orf9b impacted antiviral IFN-I signaling.
We monitored human interferon-β (IFN-β) promoter activity in the presence or absence of …

… In contrast to our results, a lack of IFN response in HAE cells exposed to SARS-CoV-2
was recently reported (44). Of note, viral production in the HAE model we used was several …