Pharmacological importance of TG12 from tachykinin and its toxicological behavior against multidrug-resistant bacteria Klebsiella pneumonia

SV Raju, P Sarkar, M Pasupuleti, NT Saraswathi… - … & Pharmacology, 2021 - Elsevier
Abstract Development of antimicrobial drugs against multidrug-resistant (MDR) bacteria is a
great focus in recent years. TG12, a short peptide molecule used in this study was screened …

Peptides as a therapeutic strategy against Klebsiella pneumoniae

CM de Souza, ÁP da Silva, NGO Júnior… - … in Pharmacological …, 2022 - cell.com
Klebsiella pneumoniae is considered a world health problem due to high levels of mortality
associated with resistance to multiple antibiotics. Antimicrobial peptides (AMPs) have …

Potential therapeutic targets of Klebsiella pneumoniae: a multi-omics review perspective

S Ali, M Alam, GM Hasan… - Briefings in functional …, 2022 - academic.oup.com
… was observed compared to the encapsulated strains pointing to the importance of CPS in K.
… the development of pharmacological inhibitors against Klebsiella pneumoniae drug targets. …

Review of therapeutic options for infections with carbapenem-resistant Klebsiella pneumoniae

RG Bandick, S Mousavi, S Bereswill… - European Journal of …, 2020 - akjournals.com
Infections with multi-drug resistant (MDR) bacteria including carbapenem-resistant Klebsiella
pneumoniae are emerging worldwide but are difficult to treat with the currently available …

Antimicrobial activity of plant extracts against carbapenem-producing Klebsiella pneumoniae and in vivo toxicological assessment

NG Vasconcelos, MSM Vaz, JAS Radai… - Journal of Toxicology …, 2020 - Taylor & Francis
… These families are important as a source of several secondary metabolites with promising …
However, the interaction test with different pharmacological classes of antibiotics through the …

A Review on the impacts of Azadirachta indica on Multi-drug Resistant Extended Spectrum Beta Lactamase-positive of Escherichia coli and Klebsiella pneumonia

FMB Al-Sarraj - Advancements in Life Sciences, 2021 - als-journal.com
… In this investigation, the medicinal and pharmacological properties of A. indica from neem
… Antifungal activity of different neem leaf extracts and the nimonol against some important

The potential of plant-derived secondary metabolites as novel drug candidates against Klebsiella pneumoniae: Molecular docking and simulation investigation

SR Mahapatra, J Dey, TK Raj, V Kumar… - South African Journal of …, 2022 - Elsevier
Klebsiella pneumoniae is an important multidrug-resistant pathogen affecting humans
and a major source for hospital infections associated with high morbidity and mortality due to …

Therapeutic efficacy of novel antimicrobial peptide AA139-nanomedicines in a multidrug-resistant Klebsiella pneumoniae pneumonia-septicemia model in rats

H van der Weide, U Cossío, R Gracia… - Antimicrobial Agents …, 2020 - Am Soc Microbiol
… lungs was assessed in a rat model of pneumonia-septicemia caused by extended-spectrum
β-lactamase-producing Klebsiella pneumoniae . In this model, the therapeutic efficacy was …

A new role of metformin as an efflux pump inhibitor in Klebsiella pneumonia

H Abbas, G Shaker, R Khattab… - Journal of microbiology …, 2021 - office2.jmbfs.org
… One of the most important reasons for MDR in K. … bacteria including Klebsiella pneumoniae.
In the current study, efflux activity was observed in 93.75% of Klebsiella pneumoniae clinical …

… source of antibacterial activity on respiratory diseases induced by chlamydia pneumoniae, haemophilus influenzae, klebsiella pneumoniae and moraxella catarrhalis

LE Duțu, ML Popescu, CN Purdel, EI Ilie, EA Luță… - Diversity, 2022 - mdpi.com
… new natural remedies for Klebsiella pneumoniae infection seems to … The anti-Klebsiella
effect was investigated in different … The anti-Klebsiella activity is expressed as MIC, DIZ, or both. …