… Study Comparing Dacomitinib with Gefitinib as First-Line Treatment in Patients with Advanced Non-Small-Cell Lung Cancer and EGFR-Activating Mutations

TS Mok, Y Cheng, X Zhou, KH Lee, K Nakagawa… - Drugs, 2021 - Springer
… and Korea) with newly diagnosed NSCLC and EGFR mutation (exon 19 deletion or exon 21
… Randomization was stratified by race and EGFR mutation type. An ad hoc updated analysis …

[HTML][HTML] Efficacy and safety of afatinib for EGFR-mutant non-small cell lung cancer, compared with gefitinib or erlotinib

Y Kim, SH Lee, JS Ahn, MJ Ahn… - Cancer Research and …, 2019 - synapse.koreamed.org
… 7 trial compared afatinib with gefitinib as a first-line treatment in patients with advanced
NSCLC harboring common EGFR mutations (Del19 and the L858R point mutation) [8]. Although …

[HTML][HTML] Clonal evolution and heterogeneity of osimertinib acquired resistance mechanisms in EGFR mutant lung cancer

N Roper, AL Brown, JS Wei, S Pack, C Trindade… - Cell reports …, 2020 - cell.com
… L858R mutation later in tumor evolution consistent with previous reports inherited susceptibility
of lung cancer and heterogeneous development of sensitizing EGFR mutations in these …

[HTML][HTML] Exosome-based detection of activating and resistance EGFR mutations from plasma of non-small cell lung cancer patients

E Castellanos-Rizaldos, X Zhang, VR Tadigotla… - Oncotarget, 2019 - ncbi.nlm.nih.gov
… There is a need for a broader EGFR panel beyond looking at the EGFR T790M mutation, so
… a qPCR-based EGFR mutation panel that also includes the activating EGFR mutations. The …

… via blockade of EGFR/AKT signaling enhances anticancer activity of HER3-targeting patritumab deruxtecan in EGFR-mutated non–small cell lung cancer

K Yonesaka, J Tanizaki, O Maenishi, K Haratani… - Clinical Cancer …, 2022 - AACR
… with HER3-DXd and EGFR-TKI in EGFR-mutated NSCLC that is currently … EGFR-mutated
NSCLC tumors, not only with regard to an acquired resistance to EGFR-TKI but also in EGFR-…

AURKB as a target in non-small cell lung cancer with acquired resistance to anti-EGFR therapy

J Bertran-Alamillo, V Cattan, M Schoumacher… - Nature …, 2019 - nature.com
lung cancer (NSCLC) tumors harboring mutations in EGFR ultimately relapse to therapy with
EGFR tyrosine kinase inhibitors (EGFR … T790M or other acquired mutations are sensitive to …

[HTML][HTML] Neoantigen vaccination induces clinical and immunologic responses in non-small cell lung cancer patients harboring EGFR mutations

F Li, L Deng, KR Jackson, AH Talukder… - … of cancer, 2021 - ncbi.nlm.nih.gov
… I allotypes with the highest number of predicted binding EGFR neoantigens (<500 nM affinity)
for the most prevalent shared EGFR mutations in lung cancer. Black arrows indicate the A*…

Effect of erlotinib plus bevacizumab vs erlotinib alone on progression-free survival in patients with advanced EGFR-mutant non–small cell lung cancer: a phase 2 …

TE Stinchcombe, PA Jänne, X Wang, EM Bertino… - JAMA …, 2019 - jamanetwork.com
… Erlotinib versus standard chemotherapy as first-line treatment for European patients with
advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-…

First-line afatinib for the treatment of EGFR mutation-positive non-small-cell lung cancer in the 'real-world' clinical setting

K Park, D Wan-Teck Lim, I Okamoto… - … advances in medical …, 2019 - journals.sagepub.com
… Epidermal growth factor receptor (EGFR) tyrosine kinase … with EGFR mutation-positive
non-small-cell lung cancer (… EGFR TKIs for the first-line treatment of EGFR mutation-positive …

Accurate Classification of Non-small Cell Lung Cancer (NSCLC) Pathology and Mapping of EGFR Mutation Spatial Distribution by Ambient Mass Spectrometry …

M Zhang, J He, T Li, H Hu, X Li, H Xing, J Wang… - Frontiers in …, 2019 - frontiersin.org
EGFR-mutated-positive compared with EGFR-wild-type AC tissues. We also found EGFR
mutations … the regions with higher ions intensity of phospholipids were EGFR-mutated-positive. …