[HTML][HTML] … microenvironment in controversies regarding immune checkpoint inhibitors for the treatment of non-small cell lung cancer (NSCLC) with EGFR mutations

A Lin, T Wei, H Meng, P Luo, J Zhang - Molecular cancer, 2019 - Springer
EGFR mutations, such as the effect of EGFR tyrosine kinase inhibitors (TKIs) or EGFR mutations
… between PD-L1 axis inhibitors and EGFR mutation status. We conducted a review of this …

[HTML][HTML] Epidermal growth factor receptor (EGFR)-mutated non-small-cell lung cancer (NSCLC)

C O'Leary, H Gasper, KB Sahin, M Tang, A Kulasinghe… - Pharmaceuticals, 2020 - mdpi.com
EGFR mutations identified that the T790M mutation occurs in 0.7% of all NSCLC cases [20].
Furthermore, the T790M mutation … The T790M mutation sits within the ATP-binding pocket of …

[HTML][HTML] Worldwide prevalence of epidermal growth factor receptor mutations in non-small cell lung cancer: a meta-analysis

B Melosky, K Kambartel, M Haentschel… - Molecular Diagnosis & …, 2022 - Springer
… (EGFR) gene mutations in non-small cell lung cancer (NSCLC… a worldwide overview of EGFR
mutation and submutation (… covariates that influence EGFR mutation status in patients with …

Blockade of EGFR improves responsiveness to PD-1 blockade in EGFR-mutated non–small cell lung cancer

E Sugiyama, Y Togashi, Y Takeuchi, S Shinya… - Science …, 2020 - science.org
… by EGFR mutations can be associated with resistance to cancer immunotherapy, … EGFR
signal inhibitors should augment the antitumor efficacy. In patients with advanced EGFR-mutated

[HTML][HTML] Mechanisms and management of 3rd‑generation EGFR‑TKI resistance in advanced non‑small cell lung cancer

J He, Z Huang, L Han, Y Gong… - … journal of oncology, 2021 - spandidos-publications.com
… treatments for patients with advanced EGFRmutated non‑small cell lung cancer (NSCLC),
and … , EGFR T790M mutation is the primary mechanism of 1st‑ and 2nd‑generation EGFR‑TKI …

[HTML][HTML] EGFR-mutated non-small cell lung cancer and resistance to immunotherapy: role of the tumor microenvironment

C Madeddu, C Donisi, N Liscia, E Lai… - International Journal of …, 2022 - mdpi.com
… with EGFR-mutated lung cancer naïve for EGFR-TKI, even in the presence of high PD-L1
expression, the efficacy of this ICI could be influenced by TME changes during the EGFR-TKI …

[HTML][HTML] The presence of concomitant mutations affects the activity of EGFR tyrosine kinase inhibitors in EGFR-mutant non-small cell lung cancer (NSCLC) patients

AM Rachiglio, F Fenizia, MC Piccirillo, D Galetta… - Cancers, 2019 - mdpi.com
… KRAS mutation and sub-clonal EGFR mutation do not benefit from treatment with EGFR TKIs…
patients with apparent clonal EGFR mutation and sub-clonal KRAS mutation had a median …

[HTML][HTML] EGFR-A763_Y764insFQEA is a unique exon 20 insertion mutation that displays sensitivity to approved and in-development lung cancer EGFR tyrosine kinase …

PENS Vasconcelos, C Gergis, H Viray… - JTO clinical and …, 2020 - Elsevier
EGFR exon 20–specific (poziotinib, mobocertinib [TAK-788]) TKIs. We also compiled
outcomes of EGFR-A763_Y764insFQEA-mutated lung cancers treated with EGFR TKIs. …

[HTML][HTML] First- and Second-Generation EGFR-TKIs Are All Replaced to Osimertinib in Chemo-Naive EGFR Mutation-Positive Non-Small Cell Lung Cancer?

M Takeda, K Nakagawa - International journal of molecular sciences, 2019 - mdpi.com
… of those patients with EGFR mutation–positive NSCLC. Although there are five EGFR-TKIs
(… currently available for the treatment of EGFR-mutated lung cancer, the optimal sequence for …

Efficacy and Safety of Patritumab Deruxtecan (HER3-DXd) in EGFR Inhibitor–Resistant, EGFR-Mutated Non–Small Cell Lung Cancer

PA Jänne, C Baik, WC Su, ML Johnson, H Hayashi… - Cancer discovery, 2022 - AACR
… In addition, most first-line osimertinib-resistant lung cancers do not harbor an obvious, …
In this study, we explored a ubiquitous biological feature of EGFR-mutated lung cancers, the …